DECREASED GLUCOSE-UTILIZATION IN THE STRIATUM AND FRONTAL-LOBE IN PROBABLE STRIATONIGRAL DEGENERATION
DECREASED GLUCOSE-UTILIZATION IN THE STRIATUM AND FRONTAL-LOBE IN PROBABLE STRIATONIGRAL DEGENERATION
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DOI：
10.1002/ana.410260210
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发表时间：
1989-08-01
影响因子：
11.2
通讯作者：
GOFFINET, AM
中科院分区：
文献类型：
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作者：
DEVOLDER, AG;FRANCART, J;GOFFINET, AM
我们对7例可能患有纹状体变性的患者进行了9次区域脑糖代谢的正电子发射断层扫描研究，纹状体变性是一种以帕金森病为特征的疾病，对左旋多巴没有反应或反应差。与正常志愿者相比，纹状体变性患者的平均脑糖代谢略有降低，此外，壳核和尾状核的代谢明显降低（20.5%，±3 SD）。在运动/前运动以及前额皮质也发现了显著的低代谢。在两次研究的2名受试者中，纹状体相对代谢的恶化与临床进展平行。核磁共振显示所有病例壳核内均有异常铁质沉积，但未见皮质异常。这些结果表明，使用[18F]氟脱氧葡萄糖的正电子发射断层扫描可以提供纹状体变性中纹状体细胞和过程退化的指标，并能够检测额叶皮质的功能缺陷。纹状体低代谢的存在可能是左旋多巴不良反应的一个预测因子。
Nine positron emission tomography studies of regional cerebral glucose metabolism were performed in 7 patients with probable striatonigral degeneration, a disorder characterized by parkinsonian features and absent or poor response to L‐dopa. When compared with values obtained in normal volunteers, mean cerebral glucose metabolism was slightly reduced in subjects with striatonigral degeneration who, in addition, had a marked (20.5%, ± 3 SD) relative hypometabolism in putaminal and caudate nuclei. Significant hypometabolism was also found in motor/premotor as well as in prefrontal cortex. In 2 subjects who were studied twice a deterioration of relative striatal metabolism paralleled clinical evolution. Magnetic resonance imaging disclosed the presence of abnormal iron deposits in the putamen in all cases but showed no cortical anomalies. These results suggest that positron emission tomography with [18F] fluorodeoxyglucose may provide an index of cell and processes degeneration in the striatum in striatonigral degeneration and is able to detect functional deficits in frontal cortex. The presence of striatal hypometabolism might be a predictor of a poor reponse to L‐dopa.