ACTIVATION OF SUPPRESSOR T CELLS BY TUMOR-CELLS AND SPECIFIC ANTIBODY
ACTIVATION OF SUPPRESSOR T CELLS BY TUMOR-CELLS AND SPECIFIC ANTIBODY
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DOI：
10.1038/250594a0
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发表时间：
1974-01-01
期刊：
影响因子：
64.8
通讯作者：
MITCHELL, MS
中科院分区：
文献类型：
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作者：
GERSHON, RK;MOKYR, MB;MITCHELL, MS
被动给药抗体的免疫抑制早已为人所知（见文献1），由于抗体可引起肿瘤生长增强2,3，抗体介导的免疫抑制在肿瘤免疫学中的作用已得到特别关注。Hellstromet等人强调，阻断因子，最可能是抗原-抗体复合物，抑制细胞介导的免疫，因此在肿瘤生长的进程中起着重要作用。这些阻断因子可能是诱导和/或维持某些形式的免疫耐受的重要因素6 - 8。但其机制仍不清楚。
IMMUNOSUPPRESSION by passively administered antibody has long been known (see ref. 1 for review) and as antibody can cause enhancement of tumour growth2,3, particular attention has been paid to the role of antibody-mediated immunosuppression in tumour immunology. Hellstromet al.have emphasised that blocking factors, most likely antigen-antibody complexes4, suppress cell-mediated immunity and thus play a major part in the progression of tumour growth5. Such blocking factors may be an important factor in the induction and/or maintenance of some forms of immunological tolerance6–8. But the mechanism remains obscure.