GRP78 antibodies are associated with blood-brain barrier breakdown in paraneoplastic cerebellar degeneration in Lambert-Eaton myasthenic syndrome.
GRP78 antibodies are associated with blood-brain barrier breakdown in paraneoplastic cerebellar degeneration in Lambert-Eaton myasthenic syndrome.
复制标题
GRP78 抗体与兰伯特-伊顿肌无力综合征副肿瘤性小脑变性的血脑屏障破坏相关。
DOI：
10.1111/cen3.12575
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Kanda T.
中科院分区：
文献类型：
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作者：
Shimizu F;Kanda T.
Lambert-Eaton肌无力综合征（LEMS）是一种自身免疫性神经肌肉连接疾病，与P/ q型电压门控钙通道（P/ q型VGCCs）自身抗体相关P/ q型VGCCs存在于突触前运动神经末端，其抗体诱导神经递质释放减少，导致与该疾病相关的特征性肌肉无力。血脑屏障；CNS，中枢神经系统；LEMS，兰伯特-伊顿肌无力综合征；PCD，副肿瘤小脑变性；VGCC，电压门控钙通道gl利益冲突【摘自文章】《临床与实验神经免疫学》版权归Wiley-Blackwell所有，未经版权所有者明确书面许可，其内容不得复制或通过电子邮件发送到多个网站或发布到listserv。但是，用户可以打印、下载或通过电子邮件发送文章供个人使用。这篇摘要可以删节。对副本的准确性不作任何保证。用户应参考资料的原始出版版本以获取完整摘要。版权适用于所有摘要。
GRP78 antibodies are associated with blood-brain barrier breakdown in paraneoplastic cerebellar degeneration in Lambert-Eaton myasthenic syndrome Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune neuromuscular junction disease associated with P/Q-type voltage-gated calcium channels (P/Q-type VGCCs) autoantibodies.[1] P/Q-type VGCCs present at the presynaptic motor nerve terminals and their antibodies induce a reduction in neurotransmitter release, leading to the characteristic muscle weakness associated with the disease. BBB, blood-brain barrier; CNS, central nervous system; LEMS, Lambert-Eaton myasthenic syndrome; PCD, paraneoplastic cerebellar degeneration; VGCC, voltage-gated calcium channel gl CONFLICT OF INTEREST None declared.[Extracted from the article]Copyright of Clinical & Experimental Neuroimmunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. Copyright applies to all Abstracts.