ß-Blockers in Hypertensive and Coronary Heart Disease

ß-Blockers in Hypertensive and Coronary Heart Disease
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β-受体阻滞剂治疗高血压和冠心病

DOI:
10.1001/archinte.1996.00440110025005
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发表时间:
1996
影响因子:
39
通讯作者:
S. Goldstein
S. Goldstein
中科院分区:
医学1区
文献类型:
--
作者:
S. Goldstein

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β受体阻滞剂广泛应用于心血管药物。在高血压患者中,β受体阻滞剂对卒中和冠心病预防和死亡率的临床终点显示出有益的作用。β-受体阻滞剂在改善心绞痛患者的运动耐量和减少心绞痛发作的次数和持续时间方面也得到了很好的证实。有证据表明,β受体阻滞剂可降低死亡率和发病率,是急性心肌梗死后治疗的基石。不幸的是,尽管有数据表明这些药物具有广泛的耐受性,但耐受性差的假设使这些药物在临床环境中未得到充分利用。充血性心力衰竭患者使用β受体阻滞剂可产生有益的血流动力学效应和症状改善。在为个体患者选择β受体阻滞剂时应考虑的因素包括药物在特定适应症中的有效性、耐受性、产品配方和作用持续时间以及是否存在特定特性(如心脏选择性)。(Arch 1996;156:1267-1276)
β -Blockers are widely used in cardiovascular medicine. In patients with hypertension, β-blockers show beneficial effects on clinical end points of stroke and coronary heart disease prevention and mortality. β-Blockers also are well established in improving exercise tolerance and decreasing the number and duration of anginal attacks in patients with angina pectoris. Based on evidence showing reduced mortality and morbidity, β-blockers are the cornerstone of therapy after acute myocardial infarction. Unfortunately, presumption of poor tolerance has left these drugs underutilized in this clinical setting, despite data that indicate a wide range of tolerability. The use of β-blockers in patients with congestive heart failure results in beneficial hemodynamic effects and symptomatic improvement. Among factors that should be considered when selecting a β-blocker for an individual patient are demonstrated efficacy of the drug in a specific indication, tolerability, product formulation and duration of action, and the presence or absence of specific properties such as cardioselectivity. (Arch Intern Med. 1996;156:1267-1276)
β-肾上腺素能阻滞药物对实验性心室颤动阈值的比较影响。
DOI: 10.1016/0002-9149(83)90368-5
发表时间: 1983
期刊: The American journal of cardiology
影响因子: --
作者:
Anderson,JL;Rodier,HE;Green,LS
通讯作者: Green,LS
慢性β-肾上腺素能阻断可降低患有高血压和左心室肥厚的狗与冠状动脉闭塞相关的心源性猝死的发生率。
DOI: 10.1161/01.cir.82.3.941
发表时间: 1990
期刊: Circulation
影响因子: 37.8
作者:
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DOI: 10.1161/01.cir.88.1.92
发表时间: 1993-07-01
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影响因子: 37.8
作者:
ANDREWS, TC;FENTON, T;STONE, PH
通讯作者: STONE, PH
急性心肌梗死后二级预防的动脉粥样硬化血栓形成见解。
DOI: --
发表时间: 1993
期刊: The Canadian journal of cardiology
影响因子: --
作者:
Rabbani,LE;Loscalzo,J
通讯作者: Loscalzo,J
DOI: 10.1161/01.cir.82.6.1962
发表时间: 1990
期刊: Circulation
影响因子: 37.8
作者:
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通讯作者: Raby,K