Treatment of alcoholic liver disease
Treatment of alcoholic liver disease
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DOI：
10.1159/000090175
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发表时间：
2005-01-01
影响因子：
2.3
通讯作者：
Arteel, GE
中科院分区：
文献类型：
--
作者：
Bergheim, I;McClain, CJ;Arteel, GE
酒精性肝病（ALD）仍然是世界范围内发病率和死亡率的主要原因。例如，退伍军人管理局合作研究报告说，肝硬化和酒精性肝炎患者的4年死亡率>60%（比许多常见的癌症，如乳腺癌和前列腺癌更糟）。ALD治疗的基石是生活方式的改变，包括戒酒和治疗失代偿，如果合适的话。营养干预已被证明在住院病人和门诊病人中发挥积极作用。糖皮质激素在酒精性肝炎患者中是有效的，并且用戊茶碱治疗似乎是一种有希望的抗炎治疗。最近的研究表明，抗TNF α治疗，至少对酒精性肝炎。一些补充和替代药物，如水飞蓟和S-腺苷甲硫氨酸，可能是有效的酒精性肝硬化。ALD并发症的治疗可以提高生活质量，在某些情况下，可以降低短期死亡率。版权所有（C）2005 S. Karger AG，巴塞尔。
Alcoholic liver disease (ALD) remains a major cause of morbidity and mortality worldwide. For example, the Veterans Administration Cooperative Studies reported that patients with cirrhosis and superimposed alcoholic hepatitis had a 4-year mortality of >60% ( worse than many common cancers such as breast and prostate). The cornerstone for therapy for ALD is lifestyle modification, including drinking cessation and treatment of decompensation, if appropriate. Nutrition intervention has been shown to play a positive role on both an in-patient and out-patient basis. Corticosteroids are effective in selected patients with alcoholic hepatitis, and treatment with pentoxifylline appears to be a promising anti-inflammatory therapy. Recent studies have indicated anti-TNF alpha therapy, at least for alcoholic hepatitis. Some complementary and alternative medicinal agents, such as milk thistle and S-adenosylmethionine, may be effective in alcoholic cirrhosis. Treatment of the complications of ALD can improve the quality of life and, in some cases, decrease short-term mortality. Copyright (C) 2005 S. Karger AG, Basel.