Tissue Factor and Cancer: Regulation, Tumor Growth, and Metastasis
Tissue Factor and Cancer: Regulation, Tumor Growth, and Metastasis
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DOI：
10.1055/s-0039-1687894
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发表时间：
2019-06-01
影响因子：
5.7
通讯作者：
Mackman, Nigel
中科院分区：
文献类型：
--
作者：
Hisada, Yohei;Mackman, Nigel
组织因子（TF）与癌症之间存在密切关系。许多癌细胞表达高水平的全长TF和选择性剪接的TF。TF在癌症中的表达与不良预后相关。本文就TF在肿瘤细胞中的表达调控以及TF和asTF在肿瘤生长和转移中的作用作一综述。多种不同的信号通路、转录因子和微核糖核酸调节癌细胞中TF基因的表达。TF/因子VIIa复合物通过激活蛋白酶激活受体2信号传导和通过增加血管生成因子如血管内皮生长因子的表达来增强肿瘤生长。AsTF通过增强整合素β 1信号传导来增加肿瘤生长。TF和asTF还通过多种凝血酶依赖性和非依赖性机制促进转移，包括保护肿瘤细胞免受自然杀伤细胞的侵害。最后，一种新的抗癌疗法是使用肿瘤TF作为靶点向肿瘤递送细胞毒性药物。TF在癌症的诊断、预后和治疗中可能是有用的。
There is a strong relationship between tissue factor (TF) and cancer. Many cancer cells express high levels of both full-length TF and alternatively spliced (as) TF. TF expression in cancer is associated with poor prognosis. In this review, the authors summarize the regulation of TF expression in cancer cells and the roles of TF and asTF in tumor growth and metastasis. A variety of different signaling pathways, transcription factors and micro ribonucleic acids regulate TF gene expression in cancer cells. The TF/factor VIIa complex enhances tumor growth by activating protease-activated receptor 2 signaling and by increasing the expression of angiogenic factors, such as vascular endothelial growth factor. AsTF increases tumor growth by enhancing integrin beta 1 signaling. TF and asTF also contribute to metastasis via multiple thrombin-dependent and independent mechanisms that include protecting tumor cells from natural killer cells. Finally, a novel anticancer therapy is using tumor TF as a target to deliver cytotoxic drugs to the tumor. TF may be useful in diagnosis, prognosis, and treatment of cancer.