Is there an association between the use of oral contraception and depressive symptoms in young Australian women?
Is there an association between the use of oral contraception and depressive symptoms in young Australian women?
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DOI：
10.1016/j.contraception.2006.08.002
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发表时间：
2007-01-01
期刊：
影响因子：
2.9
通讯作者：
Young, Anne F.
中科院分区：
文献类型：
--
作者：
Duke, Janine M.;Sibbritt, David W.;Young, Anne F.
目的：本研究的目的是探讨口服避孕药（OCP）的使用和抑郁症状的经验之间的关系，一个有代表性的样本的年轻的澳大利亚women.Methods：研究样本来自澳大利亚妇女的健康纵向研究。分析仅限于对调查2（2000年进行，年龄在22至27岁之间）和调查3（2003年进行，年龄在25至30岁之间）做出答复的最年轻队列中的女性（n = 9688）。调整潜在混杂因素后，非使用者出现抑郁症状的几率与OCP使用者无显著差异[比值比=1.05; 95%置信区间（95%CI）=0.90-1.21]。使用OCP避孕以外的原因的妇女是1.32（95%CI = 1.07-1.62）倍，可能是抑郁的妇女使用OCP避孕。报告经历抑郁症状的妇女的百分比下降，随着使用OCP的年数增加（p=.009）。结论：本研究的结果表明，调整混杂因素后，没有独立的影响，使用OCP对抑郁症状的年轻澳大利亚妇女。(c)2007年爱思唯尔公司All rights reserved.
Purpose: The purpose of this study was to explore the relationship between oral contraceptive pill (OCP) use and the experience of depressive symptoms among a representative sample of young Australian women.Methods: The study sample comes from the Australian Longitudinal Study on Women's Health. Analysis was confined to women in the youngest cohort who responded to Survey 2, which was conducted in 2000 (n=9688) when they were aged between 22 and 27 years, and to Survey 3, which was conducted in 2003 (n=9081) when they were aged between 25 and 30 years.Results: After adjusting for potential confounders, the odds of a nonuser experiencing depressive symptoms is not significantly different from that of an OCP user [odds ratio=1.05; 95% confidence interval (95% Cl)=0.90-1.21]. Women who used OCP for reasons other than contraception were 1.32 (95% CI= 1.07-1.62) times as likely to be depressed than women who used OCP for contraception. The percentage of women who reported experiencing depressive symptoms declined as the number of years of OCP use increased (p=.009).Conclusions: The results of this study suggest that, after adjusting for confounders, there is no independent effect of OCP use on depressive symptoms in young Australian women. (c) 2007 Elsevier Inc. All rights reserved.