Abyssomicin E, a highly functionalized polycyclic metabolite from Streptomyces species
Abyssomicin E, a highly functionalized polycyclic metabolite from Streptomyces species
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DOI：
10.1021/ol0705999
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发表时间：
2007-06-21
期刊：
影响因子：
5.2
通讯作者：
Sattler, Isabel
中科院分区：
文献类型：
--
作者：
Niu, Xue-Mei;Li, Sheng-Hong;Sattler, Isabel
从Streptomyces sp. （HKI0381）中分离到C19骨架的新多环代谢物Abyssomicin E(1)。通过核磁共振和质谱综合分析确定了其化学结构。在这类新发现的化合物中，首次使用铜辐射的异常色散进行单晶x射线衍射研究，直接建立了绝对立体化学。
Abyssomicin E (1), a new polycyclic metabolite with a C19 skeleton, was isolated from Streptomyces sp. (HKI0381). Its chemical structure was determined by comprehensive NMR and MS spectroscopic analyses. For the first time in this recently discovered class of compounds, the absolute stereochemistry was directly established by subsequent single-crystal X-ray diffraction study using anomalous dispersion with copper radiation.