Group I introns: do they only go home?
Group I introns: do they only go home?
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第一组内含子：它们只回家吗？
DOI：
10.1016/0168-9525(89)90068-1
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
C. Scazzocchio
中科院分区：
文献类型：
--
作者：
C. Scazzocchio
Saccharomvces cerevisiae. Not only were some antibiotic resistance markers transferred with an efficiency nearing 100%, but the ability to transfer the markers was always cotransmitted. Donor strains were called co+, recipient strains m-, and not surprisingly the first explanatory model was inspired by bacterial sex. Budding mitochondriologists might be inspired by a series of early papers by Slonimski's group, especially numbers I and IX of the seriesL2. The physical basis for the properties of the co factor was worked out mainly by Dujon and co-workers (reviewed in Refs 3-5). The markers showing a highly directional rate of gene conversion map near an optional intron which interrupts the sequences specifying the large ribosomal RNA in the mitochondrial genome of S. cerevisiae. This intron contains an open reading frame that codes for an endonuclease. This highly specific enzyme cuts double-stranded DNA exactly at the point where the intron would have been... if it were there.The co+ strains are able to transfer the whole intron unidirectionally and replicatively to an intron-less large rRNA gene. Bordering sequences are also transferred, thus accounting for the unidirectional transfer of antibiotic resistance mitochondrial markers. Following Dujon s we shall call this activity'homing'.
影响因子：
56.9
作者：
ZAUG, AJ;CECH, TR
通讯作者：
CECH, TR