A predictive model of the cat cortical connectome based on cytoarchitecture and distance.
A predictive model of the cat cortical connectome based on cytoarchitecture and distance.
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DOI：
10.1007/s00429-014-0849-y
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发表时间：
2015-11
影响因子：
3.1
通讯作者：
Hilgetag CC
中科院分区：
文献类型：
--
作者：
Beul SF;Grant S;Hilgetag CC
大脑中的信息处理受到解剖连接的强烈限制。然而，控制皮质连接组织的原则仍然难以捉摸。在这里，我们测试了猫大脑皮层 49 个区域的皮层结构组织和连接特征之间关系的三种模型。考虑的因素是区域的相对细胞结构分化（“结构模型”）、相对空间位置（“距离模型”）或相对层次位置（“层次模型”）。细胞结构分化和空间距离（本身不相关）与区域间连接的存在密切相关，而与相对层次位置没有相关性。此外，观察到层状投射起源或终止的模式与细胞结构分化之间存在很强的相关性。此外，细胞结构分化与区域形成的皮质连接的绝对数量相关，并且不同皮质子网络之间存在特征差异，包括中心区域的“丰富俱乐部”模块。因此，猫大脑皮层区域之间的联系在很大程度上可以通过相对细胞结构分化和大脑区域空间距离这两个独立因素来解释。由于结构模型和距离模型最初都是在猕猴中制定的，因此它们在其他哺乳动物物种中的适用性表明了整体皮质组织的一般原则。本文的在线版本 (doi:10.1007/s00429-014-0849-y) 包含补充材料，可供授权用户使用。
Information processing in the brain is strongly constrained by anatomical connectivity. However, the principles governing the organization of corticocortical connections remain elusive. Here, we tested three models of relationships between the organization of cortical structure and features of connections linking 49 areas of the cat cerebral cortex. Factors taken into account were relative cytoarchitectonic differentiation (‘structural model’), relative spatial position (‘distance model’), or relative hierarchical position (‘hierarchical model’) of the areas. Cytoarchitectonic differentiation and spatial distance (themselves uncorrelated) correlated strongly with the existence of inter-areal connections, whereas no correlation was found with relative hierarchical position. Moreover, a strong correlation was observed between patterns of laminar projection origin or termination and cytoarchitectonic differentiation. Additionally, cytoarchitectonic differentiation correlated with the absolute number of corticocortical connections formed by areas, and varied characteristically between different cortical subnetworks, including a ‘rich-club’ module of hub areas. Thus, connections between areas of the cat cerebral cortex can, to a large part, be explained by the two independent factors of relative cytoarchitectonic differentiation and spatial distance of brain regions. As both the structural and distance model were originally formulated in the macaque monkey, their applicability in another mammalian species suggests a general principle of global cortical organization. The online version of this article (doi:10.1007/s00429-014-0849-y) contains supplementary material, which is available to authorized users.