Association between anthropometric measures of obesity and subclinical atherosclerosis in Bangladesh.
Association between anthropometric measures of obesity and subclinical atherosclerosis in Bangladesh.
复制标题
DOI：
10.1016/j.atherosclerosis.2013.11.035
复制
发表时间：
2014-01
期刊：
影响因子：
5.3
通讯作者：
Chen Y
中科院分区：
文献类型：
--
作者：
Ge W;Parvez F;Wu F;Islam T;Ahmed A;Shaheen I;Sarwar G;Demmer RT;Desvarieux M;Ahsan H;Chen Y
人体测量指标，如腰臀比(WHR)、腰高比(WHtR)、腰围、上臂中部(MUAC)和大腿上围(MUAC)，都与心血管疾病(CVD)的风险有关。然而，它们与亚临床动脉粥样硬化的关系尚不清楚。缺乏对正常体重人群的研究，特别是在瘦身普遍存在的亚洲国家。我们在孟加拉农村地区进行了一项横断面研究，以评估腰臀比、腰围、腰围、臀围、体重指数(BMI)、MUAC和大腿上围与颈动脉内中膜厚度(CIMT)的关系。在调整了年龄和性别后，腰围和腰围与CIMT呈正相关，而BMI与CIMT无显著相关性。在多因素分析中，在控制了年龄、性别、体重指数、吸烟状况、教育程度和收缩压后，腰臀比(0.08)或腰臀比(0.07)的标准差分别与CIMT的8.96μm(95%CI，1.12~16.81)或11.45μm(95%CI，0.86~22.04)相关。腰臀比和腰臀比与CIMT的相关性不受其他人体测量指标的影响。其他人体测量指标与CIMT的相关性并不明显。在我们相对苗条、健康的亚洲人群中，腰臀比和腰臀比似乎比其他常见的肥胖症替代品更能预测早期动脉粥样硬化。
Anthropometric measures such as waist-hip-ratio (WHR), waist-height-ratio (WHtR), waist circumference, Mid-upper arm circumference (MUAC), and upper thigh circumference, have been linked to the risk of cardiovascular disease (CVD). However, their relationships with subclinical atherosclerosis are unclear. Studies in normal-weight populations, especially in Asian countries where leanness is prevalent, are lacking. We conducted a cross-sectional study to assess the associations of WHR, WHtR, waist circumference, hip circumference, body mass index (BMI), MUAC and upper thigh circumference with carotid intima-media thickness (cIMT) among 562 middle-aged participants free of CVD in rural Bangladesh. After adjusting for age and sex, WHR and waist circumference but not BMI showed a positive significant association with cIMT. In multivariate analysis, each standard deviation (SD) increase of WHR (0.08) or WHtR (0.07) was associated with an 8.96 μm (95% CI, 1.12–16.81) or 11.45 μm (95%CI, 0.86–22.04) difference in cIMT, respectively, after controlling for age, sex, BMI, smoking status, education level, and systolic blood pressure (SBP). The associations of WHR and WHtR with cIMT were independent of the influence of other anthropometric measures. The associations of other anthropometric measures and cIMT were not apparent. In our relatively lean, healthy Asian population, WHR and WHtR appear to be better predictors of early atherosclerosis than other common surrogates of adiposity.