Stimulating dopamine D1 receptors increases the locomotor activity of developing rats.
Stimulating dopamine D1 receptors increases the locomotor activity of developing rats.
复制标题
刺激多巴胺 D1 受体可增加发育中大鼠的运动活动。
DOI：
10.1016/0014-2999(96)00417-7
复制
发表时间：
1996
影响因子：
5
通讯作者：
Walters,DE
中科院分区：
文献类型：
--
作者：
Shieh,GJ;Walters,DE
为了确定多巴胺D1受体在发育大鼠运动活动中的作用，将雄性后代习惯于动物活动监测器，然后注射多巴胺D1受体拮抗剂SCH 23390(R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2，3，4，5-tetrahydro-(1H)-3-benzazepine)，或赋形剂，并返回活动监测器。30min后，给它们注射多巴胺D1受体激动剂SKF 38393(R(+)-1-phenyl-2，3，4，5-tetrahydro-(1H)-3-benzazepine-7，8-diol)，或Vehicle，再将它们放入活动箱中，单独监测它们的运动活动1h，以窝为单位进行统计分析。注射SKF 38393的10日龄和21日龄仔鼠的运动活动显著增加。这一作用可被SCH 23390所拮抗。这些数据提供了迄今为止最有力的证据，即刺激多巴胺D1受体增加了习惯性发育大鼠的运动活动
To determine the role of dopamine D1receptors in the locomotor activity of developing rats, male offspring were habituated to an animal activity monitor and were then injected with the dopamine D1receptor antagonist, SCH 23390 (R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine), or vehicle and returned to the activity monitors. 30 min later, they were injected with the dopamine D1receptor agonist, SKF 38393 (R(+)-1-phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol), or vehicle and were again placed in the activity boxes where their locomotor activity was monitored individually for 1 h. The litter was used as the unit for statistical analyses. There was a significant increase in the locomotor activity of 10- and 21-day-old offspring injected with SKF 38393. This effect was antagonized by pretreatment with SCH 23390. These data provide the strongest evidence to date that stimulation of dopamine D1receptors increases the locomotor activity of habituated developing rats