Polydimethylsiloxane Membranes Incorporating Metal-Organic Frameworks for the Sustained Release of Antibacterial Agents.
Polydimethylsiloxane Membranes Incorporating Metal-Organic Frameworks for the Sustained Release of Antibacterial Agents.
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DOI：
10.1021/acsami.1c24921
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发表时间：
2022-03
影响因子：
9.5
通讯作者：
Mofei Shen;Xinyu Liao;Yunlei Xianyu;Donghong Liu;Tian Ding
中科院分区：
文献类型：
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作者：
Mofei Shen;Xinyu Liao;Yunlei Xianyu;Donghong Liu;Tian Ding
环糊精金属有机骨架(CD-MOF)具有较高的比表面积和良好的生物相容性，在环境领域具有巨大的应用潜力。然而，CD-MOF的亲水性阻碍了其作为载体在水中保持持续释放的能力。在本研究中，我们制备了一种对植物化学物质[咖啡酸(CA)]和银纳米粒子(Ag NPs)都具有共递送能力的CD-MOF，并将其进一步复合到聚二甲基硅氧烷(PDMS)基质中，构建了杂化膜。这种杂化膜能有效地保持CD-MOF在水中的释放能力，同时赋予PDMS在水中的溶胀能力。杂化膜在水中可实现长达48小时的缓释。此外，杂化膜的弹性模量比纯PDMS膜提高了近100%，在水中的溶胀度提高了42%，表明杂化膜具有更好的力学性能。杂化膜对大肠杆菌O157：H7(E.ColiO157：H7)和金黄色葡萄球菌(S.aureus)表现出良好的抗菌效果。我们期待这项工作将有益于CD-MOF在更多环境场景中的交付研究，特别是在水处理方面。
Cyclodextrin metal-organic frameworks (CD-MOFs) possess great potential in environmental applications due to their high specific surface area and good biocompatibility properties. However, the hydrophilicity of the CD-MOF hinders its ability to maintain a sustained release in water as a carrier. In this study, we prepared a CD-MOF that has codelivery ability for both phytochemicals [caffeic acid (CA)] and silver nanoparticles (Ag NPs) and further incorporated this material (CA@Ag@CD-MOF) into the polydimethylsiloxane (PDMS) matrix to construct a hybrid membrane. This hybrid membrane could effectively maintain the release capacity of the CD-MOF in water, while endowing PDMS with swelling ability in water. The hybrid membrane can achieve a sustained release for up to 48 h in water. In addition, the elastic modulus of the hybrid membrane increases by nearly 100%, and the swelling degree of the hybrid membrane in water increases by 42% compared with that of the pure PDMS membrane, indicating better mechanical properties. The hybrid membrane exhibits excellent antibacterial effects on Escherichia coli O157:H7 (E. coli O157:H7) and Staphylococcus aureus (S. aureus). We expect that this work will be beneficial to the delivery research of the CD-MOF in more environmental scenarios, especially in water treatment.