Long-term shedding of infectious Epstein-Barr virus after infectious mononucleosis
Long-term shedding of infectious Epstein-Barr virus after infectious mononucleosis
复制标题
DOI：
10.1086/428097
复制
发表时间：
2005-03-15
影响因子：
6.4
通讯作者：
Seigneurin, JM
中科院分区：
文献类型：
--
作者：
Fafi-Kremer, S;Morand, P;Seigneurin, JM
在传染性单核细胞增多症 (IM) 发病后 6 个月内，对 20 名患者的外周血单核细胞 (PBMC)、血浆和唾液中的 Epstein-Barr 病毒 (EBV) DNA 载量以及唾液中病毒的感染性进行了评估。所有患者的唾液中均表现出持续高的 EBV DNA 载量，这与第 180 天唾液的持续感染性相关。PBMC 中的 EBV DNA 载量从第 0 天到第 180 天显着下降（尽管 90% 的患者在第 30 天到第 90 天之间出现病毒反弹），并且 EBV DNA 迅速从血浆中消失。这些数据表明，IM 患者在康复期间仍然具有高度传染性。
Epstein-Barr virus (EBV) DNA loads in peripheral blood mononuclear cells (PBMCs), plasma, and saliva, as well as infectivity of the virus in saliva, were evaluated in 20 patients for 6 months after the onset of infectious mononucleosis (IM). All patients displayed sustained high EBV DNA loads in the saliva, associated with a persistent infectivity of saliva at day 180. EBV DNA load in PBMCs decreased significantly from day 0 to day 180 ( in spite of a viral rebound between day 30 and day 90 in 90% of the patients), and EBV DNA rapidly disappeared from plasma. These data show that patients with IM remain highly infectious during convalescence.