Silanediol-Catalyzed Chromenone Functionalization
Silanediol-Catalyzed Chromenone Functionalization
复制标题
DOI：
10.1021/acs.orglett.6b01783
复制
发表时间：
2016-08-05
期刊：
影响因子：
5.2
通讯作者：
Mattson, Anita E.
中科院分区：
文献类型：
--
作者：
Hardman-Baldwin, Andrea M.;Visco, Michael D.;Mattson, Anita E.
在硅烷二醇催化的甲硅烷基乙烯酮缩醛与苯并吡喃鎓三氟甲磺酸盐的加成反应中观察到了有希望的对映控制水平。这种用含羰基亲核试剂对映选择性、分子间色酮官能化的罕见例子在生物活性色满酮和四氢氧杂蒽酮的合成中具有潜在的应用。
Promising levels of enantiocontrol are observed in the silanediol-catalyzed addition of silyl ketene acetals to benzopyrylium triflates. This rare example of enantioselective, intermolecular chromenone functionalization with carbonyl containing nucleophiles has potential applications in the synthesis of bioactive chromanones and tetrahydroxanthones.