Target structures involved in natural killing (NK): characteristics, distribution, and candidate molecules.
Target structures involved in natural killing (NK): characteristics, distribution, and candidate molecules.
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自然杀伤 (NK) 涉及的目标结构：特征、分布和候选分子。
DOI：
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发表时间：
1991
影响因子：
1.3
通讯作者：
Jeffrey R. Dawson
中科院分区：
文献类型：
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作者：
W. Storkus;Jeffrey R. Dawson
自然杀伤（NK）细胞包含重要的免疫效应细胞群，其涉及针对肿瘤转移和病毒感染的宿主细胞的监视、体液免疫应答的抑制和造血的调节。这些不同的功能需要NK效应细胞和目标靶细胞之间的初始同源相互作用。这种特异性相互作用触发NK因子的分泌（即，淋巴因子、细胞溶解物质），其介导NK活性。刺激NK反应的靶结构（TS）仍然不明确。虽然明显的TS异质性可能导致难以分离不同的NK-TS，但提出的NK细胞-靶细胞相互作用的多因素性质可能代表了寻找特定TS的主要复杂性。粘附分子如ICAM-1和LFA-3可加强NK细胞-靶细胞相互作用，而MHC抗原可减弱NK细胞-靶细胞相互作用。以下文章分析了目前认为与NK细胞识别靶细胞相关的分子相互作用。
Natural killer (NK) cells comprise an important immune effector population that has been implicated in surveillance against tumor metastases and virally infected host cells, suppression of the humoral immune response, and regulation of hematopoiesis. These diverse functions require an initial cognate interaction between the NK effector cell and the target cell of interest. This specific interaction triggers the secretion of NK factors (i.e., lymphokines, cytolytic substances) which mediate NK activity. The target structures (TS) that stimulate the NK response remain ill-defined. While apparent TS heterogeneity may contribute to the difficulty in isolating distinct NK-TS, the proposed multifactorial nature of the NK cell-target cell interaction may represent the major complexity in the search for specific TS. Adhesion molecules such as ICAM-1 and LFA-3 may strengthen, while MHC antigens may weaken, the NK cell-target cell interaction. The following article analyzes the molecular interactions currently held to be relevant in target cell recognition by NK cells.