Artificial Compounds Differentially Control Dictyostelium Chemotaxis and Cell Differentiation
Artificial Compounds Differentially Control Dictyostelium Chemotaxis and Cell Differentiation
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DOI：
10.1247/csf.10018
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发表时间：
2011-01-01
影响因子：
1.5
通讯作者：
Kubohara, Yuzuru
中科院分区：
文献类型：
--
作者：
Kuwayama, Hidekazu;Kikuchi, Haruhisa;Kubohara, Yuzuru
分化诱导因子-1和-2（DIF-1和DIF-2）是小的亲脂性信号分子，控制细胞粘菌盘基网柄菌中的细胞分化和趋化性。在这项研究中，我们研究了 DIF-1 的四种酰胺衍生物对茎细胞分化和趋化性的影响。 DIF 衍生物对细胞分化和趋化性的影响存在差异，表明可能存在至少三种 DIF 受体：一种负责茎细胞诱导，两种受体负责趋化性调节。此外，我们的结果表明 DIF 衍生物可用于分析 DIF 信号通路。
Differentiation- inducing factor-1 and -2 (DIF-1 and DIF-2) are small lipophilic signal molecules that control both cell differentiation and chemotaxis in the cellular slime mold Dictyostelium discoideum. In this study, we examined the effects of four amide derivatives of DIF-1 on stalk cell differentiation and chemotaxis. The DIF derivatives differentially affected cell differentiation and chemotaxis, suggesting the possible existence of at least three receptors for DIFs: one receptor responsible for stalk cell induction, and two receptors responsible for chemotaxis modulation. Furthermore, our results indicate that DIF derivatives can be utilized to analyze the DIF-signaling pathways.