Symbiotic Bacterium-Derived Organic Acids Protect Delia antiqua Larvae from Entomopathogenic Fungal Infection.
Symbiotic Bacterium-Derived Organic Acids Protect Delia antiqua Larvae from Entomopathogenic Fungal Infection.
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共生细菌衍生的有机酸保护迪莉娅古幼虫免受昆虫病原真菌感染
DOI：
10.1128/msystems.00778-20
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发表时间：
2020-11-17
期刊：
影响因子：
6.4
通讯作者：
Zhang X
中科院分区：
文献类型：
--
作者：
Zhou F;Xu L;Wu X;Zhao X;Liu M;Zhang X
过去 100 年来，人们对保护动物宿主免受病原体感染的相关微生物群进行了广泛的研究。然而，这些微生物如何保护动物宿主仍不清楚。在以前的研究中，一种昆虫的体表微生物，
迪莉娅·安提卡
，保护昆虫幼虫免受昆虫病原体的感染
白僵菌
。通过比较保护昆虫的微生物和不能保护昆虫的微生物产生的代谢产物，回答了微生物如何保护昆虫的问题。事实证明，体表细菌会产生一种代谢混合物，抑制细菌的定植。
B.
白僵菌
从而保护昆虫。这项工作揭示了具有抗真菌活性的新型分子，这可能有助于发现和扩展用于治疗传染病的新的预防和治疗性天然化学物质。
The protection of associated microbiota for their animal hosts against pathogen infection has been studied widely over the last 100 years. However, how those microbes protect the animal host remains unclear. In former studies, body surface microbes of one insect,
Delia antiqua
, protected the insect larvae from infection with the entomopathogen
Beauveria bassiana
. By comparing the metabolites produced by microbes that protect the insect and microbes that cannot protect the insect, the question of how the microbes protect the insect is answered. It turns out that body surface bacteria produce a metabolite cocktail that inhibits colonization of
B.
bassiana
and consequently protects the insect. This work reveals novel molecules with antifungal activity, which may aid in discovery and expansion of new prophylactic and therapeutic natural chemicals for treating infectious diseases.