Independent and combined effects of cognitive and physical activity on incident MCI
Independent and combined effects of cognitive and physical activity on incident MCI
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DOI：
10.1016/j.jalz.2014.11.007
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发表时间：
2015-11-01
影响因子：
14
通讯作者：
Ganguli, Mary
中科院分区：
文献类型：
--
作者：
Hughes, Tiffany F.;Becker, James T.;Ganguli, Mary
简介：本研究的目的是检查晚年认知活动（CA）和体力活动（PA）对轻度认知功能障碍（MCI）风险的独立和联合影响。我们使用区间删失生存模型来检查MCI事件的风险（临床痴呆评分[CDR] = 0.5）作为CA的函数（高与低）和至少中等强度PA结果：在三个年度随访波中，72名参与者发展为MCI。与无PA的低CA相比，观察到任何PA的高CA的MCI风险显著降低（风险比（HR）= 0.20，95%置信区间（CI）0.07-0.52）和任何PA的低CA（HR = 0.52，95%CI 0.29-0.93），但不适用于高CA无PA（HR = 0.94，95%CI 0.45-1.95）。(C)2015年，阿尔茨海默氏症协会。由爱思唯尔公司出版All rights reserved.
Introduction: The objective of this study was to examine the independent and combined influences of late-life cognitive activity (CA) and physical activity (PA) on the risk of incident mild cognitive impairment (MCI).Methods: We used interval censored survival modeling to examine the risk of incident MCI (Clinical Dementia Rating [CDR] = 0.5) as a function of CA (high vs. low) and at least moderate intensity PA (any vs. none) among 864 cognitively normal (CDR = 0) older adults.Results: During three annual follow-up waves, 72 participants developed MCI. Compared with low CA with no PA, significant reductions in risk for MCI were observed for high CA with any PA (hazards ratio (HR) = 0.20, 95% confidence interval (CI) 0.07-0.52) and low CA with any PA (HR = 0.52, 95% CI 0.29-0.93), but not for high CA without PA (HR = 0.94, 95% CI 0.45-1.95).Discussion: These findings suggest that a combination of CA and PA may be most efficacious at reducing the risk for cognitive impairment. (C) 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.