The relationship between Lin28 and the chemotherapy response of gastric cancer.
The relationship between Lin28 and the chemotherapy response of gastric cancer.
复制标题
Lin28与胃癌化疗反应的关系
DOI：
10.2147/ott.s45705
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发表时间：
2013
影响因子：
4
通讯作者：
Wang LB
中科院分区：
文献类型：
--
作者：
Teng RY;Zhou JC;Jiang ZN;Xu CY;Li ZD;Wang QC;Xu CP;Guo JF;Shen JG;Wang LB
这项研究的目的是确定干细胞生物标志物LIN28是否可以预测局部进展期胃癌患者对新辅助化疗的病理肿瘤反应。这项研究纳入了47名胃癌患者，他们在2004年7月至2012年3月期间接受了新辅助化疗，然后进行了手术。胃镜下活检癌组织，免疫组织化学方法检测Lin28在组织中的表达。统计分析确定Lin28的表达与肿瘤消退分级的关系。47例中，病理无反应29例(61.7%)，病理反应18例(38.3%)。受试者工作特征曲线分析显示，以0.325为界值的LIN28表达的组织评分可以区分病理应答和无应答。多变量分析显示，Lin28表达是新辅助化疗疗效的独立预测因素(P=0.006)。在接受新辅助化疗的局部进展期胃癌患者中，LIN28的表达与肿瘤病理反应有关。这可能提示LIN28可以作为预测胃癌患者新辅助化疗的生物标志物。
The aim of the study reported here was to identify whether a stem cell biomarker, Lin28, may predict the pathologic tumor response to neoadjuvant chemotherapy for patients with locally advanced gastric cancer. The study enrolled 47 patients with gastric cancer who underwent neoadjuvant chemotherapy followed by surgery between July 2004 and March 2012. Cancer tissue was biopsied by gastroscopy and Lin28 expression in the tissue was measured by immunohistochemistry. Statistical analyses were performed to identify the relationship between Lin28 expression and tumor regression grade. Of the 47 cases, pathologic nonresponse was observed in 29 (61.7%) and pathologic response in 18 (38.3%). Receiver-operating characteristic curve analysis showed that the histoscore of Lin28 expression with 0.325 as a cutoff value could differentiate between pathologic response and nonresponse. Multivariable analysis showed that Lin28 expression was an independent predictive factor for pathologic response to neoadjuvant chemotherapy (P = 0.006). Lin28 expression was associated with pathologic tumor response in locally advanced gastric cancer patients undergoing neoadjuvant chemotherapy. This may suggest that Lin28 can serve as a predictive biomarker for neoadjuvant chemotherapy in patients with gastric cancer.