Pharmacological activation of KCa3.1/KCa2.3 channels produces endothelial hyperpolarization and lowers blood pressure in conscious dogs
Pharmacological activation of KCa3.1/KCa2.3 channels produces endothelial hyperpolarization and lowers blood pressure in conscious dogs
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DOI：
10.1111/j.1476-5381.2011.01546.x
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发表时间：
2012-01-01
影响因子：
7.3
通讯作者：
Kohler, Ralf
中科院分区：
文献类型：
--
作者：
Damkjaer, Mads;Nielsen, Gorm;Kohler, Ralf
背景和目的 在啮齿类动物中，内皮 KCa 通道 KCa3.1 和 KCa2.3 已被证明在启动内皮源性超极化因子 (EDHF) 血管舒张反应中发挥着至关重要的作用。然而，目前尚不清楚这些通道在多大程度上参与大型哺乳动物的血压调节，这也将使我们能够解决安全问题。因此，我们表征了犬内皮 KCa3.1 和 KCa2.3 功能，并评估了 KCa3.1/KCa2.3 激活剂 SKA-31 对狗血压和心率的影响。
BACKGROUND AND PURPOSE In rodents, the endothelial KCa channels, KCa3.1 and KCa2.3, have been shown to play a crucial role in initiating endothelium-derived hyperpolarizing factor (EDHF) vasodilator responses. However, it is not known to what extent these channels are involved in blood pressure regulation in large mammals, which would also allow us to address safety issues. We therefore characterized canine endothelial KCa3.1 and KCa2.3 functions and evaluated the effect of the KCa3.1/KCa2.3 activator SKA-31 on blood pressure and heart rate in dogs.