Eating on nightshift: A big vs small snack impairs glucose response to breakfast
Eating on nightshift: A big vs small snack impairs glucose response to breakfast
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DOI：
10.1016/j.nbscr.2017.12.001
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发表时间：
2018-01-01
影响因子：
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通讯作者：
Banks, Siobhan
中科院分区：
文献类型：
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作者：
Centofanti, Stephanie;Dorrian, Jillian;Banks, Siobhan
轮班工作是2型糖尿病等慢性疾病的危险因素。食物的选择可能起着一定的作用，但是在晚上身体准备睡觉的时候简单地吃东西可能会对健康产生影响。这项研究调查了晚上吃大零食和小零食对葡萄糖代谢的影响。N = 31名健康受试者（21- 35岁; 18名女性）参加了一项模拟夜班实验室研究，该研究包括一个基线睡眠夜晚（22：00 h-07：00 h）和一个夜晚清醒，并分配到大零食（2100 kJ）或小零食（840 kJ）组。零食在00：00-00：30之间食用，由低脂牛奶、三明治、薯条和水果（大零食）或半个三明治和水果（小零食）组成。受试者吃了相同的混合餐早餐（2100千焦）在08：30小时后，一个完整的睡眠和模拟夜班。在整个研究期间，使用Medtronic Continual Glucose ™连续测量间质葡萄糖。仅分析早餐摄入量相同且数据集完整的受试者（N = 20）。将葡萄糖数据平均到5分钟箱中，并计算早餐后90分钟的曲线下面积（AUC）。早餐前，第1天和第2天之间的血糖水平没有显著差异，零食组之间也没有显著差异（p > 0.05）。发现零食组与日间的相互作用效应（F-1，F-16 = 5.36，p = 0.034），并且post-hoc显示，在大量零食组中，与第1天相比，夜班后（第2天）对早餐的AUC响应显著更高（p = 0.001）。这转化为20.8%（SEM 5.6）的增长。在小零食组中，AUC在几天之间没有显著差异。与较小的零食相比，在00：00时食用大零食会损害08：30时对早餐的葡萄糖反应。这一领域的进一步研究将为轮班工人提供饮食建议，其中可能包括关于吃多少以及内容的建议。
Shift work is a risk factor for chronic diseases such as Type 2 diabetes. Food choice may play a role, however simply eating at night when the body is primed for sleep may have implications for health. This study examined the impact of consuming a big versus small snack at night on glucose metabolism. N = 31 healthy subjects (21- 35 y; 18 F) participated in a simulated nightshift laboratory study that included one baseline night of sleep (22:00 h-07:00 h) and one night awake with allocation to either a big snack (2100 kJ) or small snack (840 kJ) group. The snack was consumed between 00:00-00:30 h and consisted of low fat milk, a sandwich, chips and fruit (big snack) or half sandwich and fruit (small snack). Subjects ate an identical mixed meal breakfast (2100 kJ) at 08:30 h after one full night of sleep and a simulated nightshift. Interstitial glucose was measured continuously during the entire study using Medtronic Continual Glucose Monitors. Only subjects with identical breakfast consumption and complete datasets were analysed (N = 20). Glucose data were averaged into 5-minute bins and area under the curve (AUC) was calculated for 90 min post-breakfast. Pre-breakfast, glucose levels were not significantly different between Day1 and Day2, nor were they different between snack groups (p > 0.05). A snack group by day interaction effect was found (F-1,F-16 = 5.36, p = 0.034) and post-hocs revealed that in the big snack group, AUC response to breakfast was significantly higher following nightshift (Day2) compared to Day1 (p = 0.001). This translated to a 20.8% (SEM 5.6) increase. AUC was not significantly different between days in the small snack group. Consuming a big snack at 00:00 h impaired the glucose response to breakfast at 08:30 h, compared to a smaller snack. Further research in this area will inform dietary advice for shift workers, which could include recommendations on how much to eat as well as content.