Cholinergic enhancement modulates neural correlates of selective attention and emotional processing
Cholinergic enhancement modulates neural correlates of selective attention and emotional processing
复制标题
DOI：
10.1016/s1053-8119(03)00302-1
复制
发表时间：
2003-09-01
期刊：
影响因子：
5.7
通讯作者：
Dolan, RJ
中科院分区：
文献类型：
--
作者：
Bentley, P;Vuilleumier, P;Dolan, RJ
新皮质胆碱能传入被认为影响选择性注意和情绪处理。在一项针对健康成年人的研究中，我们使用事件相关功能磁共振成像，同时正交操纵注意力和情绪，以检查抗胆碱酯酶毒扁豆碱对胆碱能调节作用的区域。无论是脸或房子的图片出现在任务相关的位置，与替代图片类型在无关的位置。他们的表情要么是中性的，要么是恐惧的。毒扁豆碱增加了前梭状回内的相对活动，在出席，与无人值守，位置的面孔，但减少后外侧枕叶皮质内的相对活动，在出席，与无人值守，位置的房屋。在没有刺激的情况下，毒扁豆碱对线索诱发反应的影响也存在类似的区域差异。胆碱能增强增强梭状回中的相对神经元的反应，可怕的面孔，无论是在出席或无人值守的位置。相比之下，毒扁豆碱影响的反应，在眶额，顶内和扣带皮层恐惧的面孔时，面孔占据任务无关的位置。这些研究结果表明，乙酰胆碱可能通过独立的，特定区域的影响外纹皮层调节选择性注意和情绪过程。此外，胆碱能输入额顶叶皮层可能会影响注意力的分配情绪信息。(C)2003年爱思唯尔公司All rights reserved.
Neocortical cholinergic afferents are proposed to influence both selective attention and emotional processing. In a study of healthy adults we used event-related fMRI while orthogonally manipulating attention and emotionality to examine regions showing effects of cholinergic modulation by the anticholinesterase physostigmine. Either face or house pictures appeared at task-relevant locations, with the alternative picture type at irrelevant locations. Faces had either neutral or fearful expressions. Physostigmine increased relative activity within the anterior fusiform gyrus for faces at attended, versus unattended, locations, but decreased relative activity within the posterolateral occipital cortex for houses in attended, versus unattended, locations. A similar pattern of regional differences in the effect of physostigmine on cue-evoked responses was also present in the absence of stimuli. Cholinergic enhancement augmented the relative neuronal response within the middle fusiform gyrus to fearful faces, whether at attended or unattended locations. By contrast, physostigmine influenced responses in the orbitofrontal, intraparietal and cingulate cortices to fearful faces when faces occupied task-irrelevant locations. These findings suggest that acetylcholine may modulate both selective attention and emotional processes through independent, region-specific effects within the extrastriate cortex. Furthermore, cholinergic inputs to the frontoparietal cortex may influence the allocation of attention to emotional information. (C) 2003 Elsevier Inc. All rights reserved.