Poly(vinyl alcohol)-acrylamide hydrogels as load-bearing cartilage substitute
Poly(vinyl alcohol)-acrylamide hydrogels as load-bearing cartilage substitute
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DOI：
10.1016/j.biomaterials.2008.10.010
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发表时间：
2009-02-01
期刊：
影响因子：
14
通讯作者：
Muratoglu, Orhun K.
中科院分区：
文献类型：
--
作者：
Bodugoz-Senturk, Hatice;Macias, Celia E.;Muratoglu, Orhun K.
聚乙烯醇(PVA)具有粘弹性、高含水率和生物相容性等特点，已成为制造医疗器械、合成关节软骨的生物材料。这类装置的关键材料要求是高抗蠕变性能以防止关节中的机械不稳定，以及高含水率以保持光滑的表面，以最大限度地减少关节过程中软骨对应面的磨损和损坏。通过高温热处理可以提高PVA水凝胶的蠕变抗力：然而，这一过程也会使孔洞收缩，减少水分含量，从而降低水凝胶表面的润滑性[Bodugoz-Senturk H，Choi J，Oral E，Kung JH，Macias CE，Braithwaite G，等人。聚乙二醇热处理对聚乙烯醇水凝胶孔稳定性的影响。生物材料2008；29(2)：141-9。]我们假设，在PVA水凝胶的孔中聚合丙烯酰胺(AAM)将通过防止孔的坍塌和水分的损失来最大限度地减少在热处理过程中的润滑性损失。随着AAm含量的增加，PVA水凝胶的孔隙率和平衡水含量增加，摩擦系数、撕裂强度、结晶度和抗蠕变性能降低。(C)2008爱思唯尔有限公司。保留所有权利。
Poly(vinyl alcohol) (PVA) has been advanced as a biomaterial for the fabrication of medical devices to be used as synthetic articular cartilage because of its viscoelastic nature, high water content, and biocompatibility. Key material requirements for such devices are high creep resistance to prevent mechanical instability in the joint and high water content to maintain a lubricious surface to minimize wear and damage of the cartilage counterface during articulation. The creep resistance of PVA hydrogels can be increased by high temperature annealing: however this process also collapses the pores, reducing the water content and consequently reducing the lubricity of the hydrogel surface [Bodugoz-Senturk H, Choi J, Oral E, Kung JH, Macias CE, Braithwaite G, et al. The effect of polyethylene glycol on the stability of pores in polyvinyl alcohol hydrogels during annealing. Biomaterials 2008;29(2):141-9.]. We hypothesized that polymerizing acrylamide (AAm) in the pores of the PVA hydrogel Would minimize the loss of lubricity during annealing by preventing the collapse of the pores and loss of water content. Increasing AAm content increased porosity and equilibrium water content and decreased the coefficient of friction, tear strength, crystallinity, and creep resistance in annealed PVA hydrogels. (C) 2008 Elsevier Ltd. All rights reserved.