The humoral and cellular responses induced locally and systemically after parenteral influenza vaccination in man
The humoral and cellular responses induced locally and systemically after parenteral influenza vaccination in man
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DOI：
10.1016/j.vaccine.2006.05.041
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发表时间：
2006-11-10
期刊：
影响因子：
5.5
通讯作者：
Brokstad, Karl Albert
中科院分区：
文献类型：
--
作者：
Cox, Rebecca Jane;Haaheim, Lars Reinhardt;Brokstad, Karl Albert
对人类接种流感疫苗后的免疫应答进行研究，重点关注粘膜表面和相关淋巴组织局部发生的免疫活性，为流感免疫提供了有价值的见解。流感疫苗的目的是发展免疫记忆，从而在随后遇到流感时增强快速特异性反应。扁桃体被认为作为针对流感的免疫应答的激活、效应器和记忆位点发挥重要作用。我们已经证明，正常情况下，健康成人的鼻粘膜中存在大量流感特异性抗体分泌细胞（ASC），但在胃肠外接种后，这些细胞的数量保持稳定。然而，接种疫苗后，在扁桃体和外周血中观察到流感特异性ASC的快速一过性增加。在扁桃体和血液中，胃肠外接种导致接种后CD4（+）细胞显著减少，这些细胞可能被募集到引流淋巴结。(c)2006爱思唯尔有限公司版权所有。
Studies of the immune response after influenza vaccination in man, with focus on the immune activity occurring locally at mucosal surfaces and in associated lymphoid tissue, provide a valuable insight into immunity to influenza. The aim of influenza vaccination is to develop immunological memory resulting in enhanced rapid specific response upon subsequent influenza encounter. The tonsils are thought to play an important role as an activating, effector and memory site for immune responses against influenza. We have shown that normally high numbers of influenza-specific antibody secreting cells (ASC) are present in the nasal mucosa of healthy adults but upon parenteral vaccination the numbers remain stable. However, a rapid transient increase in influenza-specific ASC is observed in the tonsils and peripheral blood after vaccination. In the tonsils and blood, parenteral vaccination results in a significant decrease in CD4(+) cells upon vaccination, which are probably recruited to the draining lymph node. (c) 2006 Elsevier Ltd. All rights reserved.