AATYK is a Novel Regulator of Oligodendrocyte Differentiation and Myelination
AATYK is a Novel Regulator of Oligodendrocyte Differentiation and Myelination
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AATYK 是少突胶质细胞分化和髓鞘形成的新型调节剂
DOI：
10.1007/s12264-018-0218-6
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发表时间：
2018-06-01
影响因子：
5.6
通讯作者：
Zhao, Xiaofeng
中科院分区：
文献类型：
--
作者：
Jiang, Chunxia;Yang, Wanqing;Zhao, Xiaofeng
少突胶质细胞（Oligodendrocytes，OL）是髓鞘形成的神经胶质细胞，其在轴突周围形成髓鞘以确保动作电位的快速和局灶性传导。在这里，我们发现，轴突生长调节分子，AATYK（骨化相关酪氨酸激酶），上调与OL分化和髓鞘再生。因此，我们研究了它在OL分化中的作用。结果表明，AATYK基因敲低抑制了体外培养的大鼠前髓分化和髓鞘基因的表达。此外，AATYK缺陷维持了OLs的增殖状态，但不影响其存活。因此，AATYK对于OL的分化是必需的。
Oligodendrocytes (OLs) are myelinating glial cells that form myelin sheaths around axons to ensure rapid and focal conduction of action potentials. Here, we found that an axonal outgrowth regulatory molecule, AATYK (apoptosis-associated tyrosine kinase), was up-regulated with OL differentiation and remyelination. We therefore studied its role in OL differentiation. The results showed that AATYK knockdown inhibited OL differentiation and the expression of myelin genes in vitro. Moreover, AATYK-deficiency maintained the proliferation status of OLs but did not affect their survival. Thus, AATYK is essential for the differentiation of OLs.