T lymphocytes from patients with systemic lupus erythematosus are resistant to induction of autophagy
T lymphocytes from patients with systemic lupus erythematosus are resistant to induction of autophagy
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DOI：
10.1096/fj.12-206060
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发表时间：
2012-11-01
期刊：
影响因子：
4.8
通讯作者：
Pierdominici, Marina
中科院分区：
文献类型：
--
作者：
Alessandri, Cristiano;Barbati, Cristiana;Pierdominici, Marina
自噬是代谢损伤下发生的细胞保护机制，与自身免疫的发病机制有关。在这里，我们通过测量自噬标记微管相关蛋白 1 轻链 3 (LC3)-II，研究了系统性红斑狼疮 (SLE) 患者的 T 淋巴细胞与健康供体 T 淋巴细胞的自发和诱导自噬行为。除了来自 SLE 患者的 CD4(+) 初始 T 细胞具有较高的自噬水平外，SLE 患者和健康供体的 T 淋巴细胞之间的自发自噬没有发现显着差异 (P
Autophagy, the cytoprotection mechanism that takes place under metabolic impairment, has been implicated in the pathogenesis of autoimmunity. Here, we investigated the spontaneous and induced autophagic behavior of T lymphocytes from patients with systemic lupus erythematosus (SLE) compared with that of T lymphocytes from healthy donors by measuring the autophagy marker microtubule-associated protein 1 light chain 3 (LC3)-II. No significant differences in spontaneous autophagy were found between T lymphocytes from patients with SLE and from healthy donors, apart from CD4(+) naive T cells from patients with SLE in which constitutively higher levels of autophagy (P