Cdc20 in S-phase: The Banquo at Replication’s Banquet
Cdc20 in S-phase: The Banquo at Replication’s Banquet
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DOI：
10.4161/cc.3.3.748
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发表时间：
2004-03
期刊：
影响因子：
4.3
通讯作者：
C. A. Andrews;Marisa Segal;S. Reed;D. J. Clarke
中科院分区：
文献类型：
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作者：
C. A. Andrews;Marisa Segal;S. Reed;D. J. Clarke
The Anaphase Promoting Complex/Cyclosome (APC/C) is an E3 ubiquitin ligase that covalently attaches ubiquitins onto proteins to target them for proteolysis by the 26S proteasome. During mitosis, the APC/C is instrumental in allowing the cell to enter and exit from mitosis. The APC/C accomplishes this by using different specificity factors to recognize, interact with, and ubiquitylate key proteins that block cell cycle progression. The specificity factors, Cdc20p and Cdh1p, are not always associated with the APC/C and indeed they have the ability to interact with substrates in isolation. The molecular events that take place in order for Cdc20p and Cdh1p to couple substrates and APC/C are currently being resolved. Meanwhile, evidence has emerged suggesting that at least one of the specificity factors, Cdc20p, might be capable of functioning independently of the APC/C.
