Deep common ancestry of Indian and western-Eurasian mitochondrial DNA lineages
Deep common ancestry of Indian and western-Eurasian mitochondrial DNA lineages
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DOI：
10.1016/s0960-9822(00)80057-3
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发表时间：
1999-11-18
期刊：
影响因子：
9.2
通讯作者：
Villems, R
中科院分区：
文献类型：
--
作者：
Kivisild, T;Bamshad, MJ;Villems, R
大约五分之一的人类基因库主要属于居住在印度半岛的讲印欧语或德拉维亚语的人。他们基因库中的“高加索人份额”被认为主要与说印欧语的人有关。一个普遍持有的假说，虽然不是唯一的假说，认为印度雅利安人在大约4000年前大规模入侵印度[1]。最近对印度人母系遗传线粒体DNA(MtDNA)的有限分析被解释为支持这一概念[2，3]，这里，这种解释受到质疑。我们发现了当代欧洲人和印度人之间广泛而深刻的晚更新世遗传联系，这是由线粒体DNA单倍群U提供的，该单倍群涵盖了这两个群体大约五分之一的线粒体DNA谱系。我们对这一分裂的估计接近亚洲人口和欧亚大陆解剖现代人首次扩张的建议时间[4-8]，很可能早于他们扩散到欧洲。在印度人群中发现的高加索人特有的mtDNA谱系中，只有一小部分可以归因于一种相对较新的混合物。
About a fifth of the human gene pool belongs largely either to Indo-European or Dravidic speaking people inhabiting the Indian peninsula. The 'Caucasoid share' in their gene pool is thought to be related predominantly to the Indo-European speakers. A commonly held hypothesis, albeit not the only one, suggests a massive Indo-Aryan invasion to India some 4,000 years ago [1]. Recent limited analysis of maternally inherited mitochondrial DNA (mtDNA) of Indian populations has been interpreted as supporting this concept [2,3], Here, this interpretation is questioned. We found an extensive deep late Pleistocene genetic link between contemporary Europeans and Indians, provided by the mtDNA haplogroup U, which encompasses roughly a fifth of mtDNA lineages of both populations. Our estimate for this split is close to the suggested time for the peopling of Asia and the first expansion of anatomically modern humans in Eurasia [4-8] and likely pre-dates their spread to Europe. Only a small fraction of the 'Caucasoid-specific' mtDNA lineages found in Indian populations can be ascribed to a relatively recent admixture.