Association of Campylobacter pylori on the gastric mucosa with antral gastritis in children.
Association of Campylobacter pylori on the gastric mucosa with antral gastritis in children.
复制标题
胃粘膜上的幽门弯曲杆菌与儿童胃窦炎的关系。
DOI：
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发表时间：
1987
影响因子：
158.5
通讯作者：
M. Karmali
中科院分区：
文献类型：
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作者：
B. Drumm;P. Sherman;E. Cutz;M. Karmali
我们在一项前瞻性研究中调查了71名因胃肠道症状而接受上消化道内镜检查和胃活检的儿童的胃粘膜幽门弯曲杆菌定植和胃炎的组织学证据。从71名儿童中的67名（平均年龄[+/- SD]，11.4 +/- 3.8岁）获得胃窦的两份组织样本。评价一份样本的胃炎证据，并用银染色以检测形态上类似弯曲杆菌的微生物。第二份样品培养C. pylori，并使用一部分进行尿素酶筛选试验，以确定是否存在C.幽门。67例患者中有18例经组织学诊断为胃窦炎。C.在10例不明原因胃炎（原发性胃炎）患者中，7例通过胃窦粘膜培养和银染色鉴定出幽门螺杆菌，但在8例与可识别的潜在原因相关的胃炎（继发性胃炎）患者中，没有一例通过胃窦粘膜培养和银染色鉴定出幽门螺杆菌。C.在49例组织学特征正常的病例中均未发现幽门螺杆菌。尿素酶筛查试验在6名C培养阳性的患者中仅3名呈阳性。幽门。5例患者经内镜诊断为十二指肠溃疡。这五个人都有C。幽门的胃窦粘膜上，但生物体未确定的十二指肠粘膜。我们的结论是C.胃窦粘膜上的幽门特异性地与原发性胃窦胃炎相关，也可能与原发性十二指肠溃疡相关。
We investigated the presence of Campylobacter pylori colonization of the gastric mucosa and of histologic evidence of gastritis in a prospective study of 71 consecutive children undergoing upper gastrointestinal tract endoscopy and gastric biopsies because of gastrointestinal symptoms. Two tissue samples from the gastric antrum were obtained from 67 of the 71 children (mean age [+/- SD], 11.4 +/- 3.8 years). One sample was evaluated for evidence of gastritis and stained with silver to detect organisms morphologically resembling campylobacter. The second sample was cultured for C. pylori, and a portion was used to perform a urease-screening test for the presence of C. pylori. Antral gastritis was diagnosed histologically in 18 of 67 patients. C. pylori was identified by both culture and silver staining on the antral mucosa in 7 of 10 patients with unexplained gastritis (primary gastritis) but in none of 8 patients with gastritis associated with an identifiable underlying cause (secondary gastritis). C. pylori was not identified in any of the 49 cases with normal histologic features. The urease-screening test was positive in only three of six patients with a positive culture for C. pylori. Duodenal ulcers were diagnosed by endoscopy in five patients. Each of the five had C. pylori on the antral mucosa, but organisms were not identified on the duodenal mucosa. We conclude that the presence of C. pylori on the antral mucosa is specifically associated with primary antral gastritis and may also be associated with primary duodenal ulceration.