Sufficient sleep duration contributes to lower cardiovascular disease risk in addition to four traditional lifestyle factors: the MORGEN study
Sufficient sleep duration contributes to lower cardiovascular disease risk in addition to four traditional lifestyle factors: the MORGEN study
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DOI：
10.1177/2047487313493057
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发表时间：
2014-11-01
影响因子：
8.3
通讯作者：
Verschuren, W. M. Monique
中科院分区：
文献类型：
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作者：
Hoevenaar-Blom, Marieke P.;Spijkerman, Annemieke M. W.;Verschuren, W. M. Monique
充足的睡眠时间对降低心血管疾病风险的贡献，除了充足的体力活动，健康的饮食，设计MORGEN研究是一项前瞻性队列研究，包括8128名男性和9759名女性，年龄20-65岁，基线时无CVD。在1994年至1997年期间，通过自填问卷评估了（每周3.5小时骑自行车或运动）、健康饮食（地中海饮食评分5）、（适度）饮酒（每月1杯饮料）、不吸烟和充足的睡眠时间（7小时）。通过与国家登记册的联系确定心血管发病率和死亡率。调整年龄，性别，和教育level.Results的风险比和可预防的比例计算，在10-14年的随访，607复合心血管疾病事件（致命性心血管疾病，非致命性心肌梗死和中风）发生，其中129是致命的。与没有或只有一个健康生活方式因素的人相比，具有四个传统健康生活方式因素的人复合CVD的风险降低57%（HR 0.43，95% CI 0.31-0.59），致命CVD的风险降低67%（HR 0.33，95% CI 0.16-0.68）。除了四个传统的生活方式因素睡眠充足导致复合心血管疾病的风险降低65%（HR 0.35，95%CI 0.23-0.52），和83%的风险降低致命的CVD（HR 0.17，95%CI 0.07-0.43）。结论充足的睡眠和坚持所有四个传统的健康生活方式因素与降低CVD风险。当足够的睡眠时间被添加到传统的生活方式因素中时，CVD的风险进一步降低。
Background The contribution of sufficient sleep duration to lower CVD risk in addition to sufficient physical activity, a healthy diet, (moderate) alcohol consumption, and non-smoking has not been investigated yet.Design The MORGEN study is a prospective cohort study including 8128 men and 9759 women aged 20-65 years, free of CVD at baseline.Methods Sufficient physical activity (3.5h/week cycling or sports), a healthy diet (Mediterranean Diet Score 5), (moderate) alcohol consumption (1 beverage/month), non-smoking, and sufficient sleep duration (7 hours) were assessed by self-administered questionnaires between 1994 and 1997. Cardiovascular morbidity and mortality were ascertained through linkage with national registers. Hazard ratios and preventable proportions were calculated adjusted for age, sex, and educational level.Results During 10-14 years of follow up, 607 composite CVD events (fatal CVD, nonfatal myocardial infarction and stroke) occurred, of which 129 were fatal. Those with the four traditional healthy lifestyle factors had a 57% lower risk of composite CVD (HR 0.43, 95% CI 0.31-0.59) and a 67% lower risk of fatal CVD (HR 0.33, 95% CI 0.16-0.68) compared with those with none or one healthy lifestyle factor. Sleeping sufficiently in addition to the four traditional lifestyle factors resulted in a 65% lower risk of composite CVD (HR 0.35, 95% CI 0.23-0.52), and an 83% lower risk of fatal CVD (HR 0.17, 95% CI 0.07-0.43).Conclusions Sufficient sleep and adherence to all four traditional healthy lifestyle factors was associated with lower CVD risk. When sufficient sleep duration was added to the traditional lifestyle factors, the risk of CVD was further reduced.