Endothelial Cells as Key Determinants of the Tumor Microenvironment: Interaction With Tumor Cells, Extracellular Matrix and Immune Killer Cells
Endothelial Cells as Key Determinants of the Tumor Microenvironment: Interaction With Tumor Cells, Extracellular Matrix and Immune Killer Cells
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DOI：
10.1615/critrevimmunol.v30.i6.30
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发表时间：
2010-01-01
影响因子：
1.3
通讯作者：
Ruegg, Curzio
中科院分区：
文献类型：
--
作者：
Chouaib, Salem;Kieda, Claudine;Ruegg, Curzio
肿瘤微环境中除了肿瘤细胞外，还藏有多种宿主源性细胞，如内皮细胞、成纤维细胞、先天性和适应性免疫细胞等，是一个复杂且高度动态的环境，为肿瘤的发生和进展提供了非常重要的线索，肿瘤相关内皮细胞在这一过程中发挥着关键作用，一方面它们形成肿瘤相关的通过从局部预先存在的血管发芽或募集骨髓来源的内皮祖细胞来促进（血管生成）血管，以向生长中的肿瘤提供营养支持。另一方面，它们是循环血细胞、肿瘤细胞和细胞外基质之间的界面，从而在控制白细胞募集、肿瘤细胞行为和转移形成中起中心作用。低氧是调节肿瘤微环境和内皮/肿瘤细胞相互作用的关键参数。在低氧应激下，肿瘤细胞产生促进肿瘤血管生成的因子，肿瘤细胞运动和转移在这些因子中，VEGF，一种主要的血管生成调节剂，也可以在免疫耐受的控制中发挥关键作用。本文综述了内皮细胞在肿瘤微环境中的作用的一些方面，并强调了它们与肿瘤细胞的相互作用，我们还将讨论循环内皮祖细胞所起的作用，并说明它们的特征和招募到肿瘤微环境的机制，以及它们在肿瘤微环境中的作用。在肿瘤血管生成中的作用
Besides tumor cells, the tumor microenvironment harbors a variety of host-derived cells, such as endothelial cells, fibroblasts, innate and adaptive immune cells It is a complex and highly dynamic environment, providing very important cues to tumor development and progression Tumor-associated endothelial cells play a key role in this process On the one hand, they form tumor-associated (angiogenic) vessels through sprouting from locally preexisting vessels or recruitment of bone marrow-derived endothelial progenitor cells, to provide nutritional support to the growing tumor On the other hand, they are the interface between circulating blood cells, tumor cells and the extracellular matrix, thereby playing a central role in controlling leukocyte recruitment, tumor cell behavior and metastasis formation Hypoxia is a critical parameter modulating the tumor microenvironment and endothelial/tumor cell interactions Under hypoxic stress, tumor cells produce factors that promote tumor angiogenesis, tumor cell motility and metastasis Among these factors, VEGF, a main angiogenesis modulator, can also play a critical role in the control of immune tolerance This review discusses some aspects of the role of endothelial cells within tumor microenvironment and emphasizes their interaction with tumor cells, the extracellular matrix and with immune killer cells We will also address the role played by circulating endothelial progenitor cells and illustrate their features and mechanism of recruitment to the tumor microenvironment and their role in tumor angiogenesis