Collapsing glomerulopathy
Collapsing glomerulopathy
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DOI：
10.1681/asn.2006030225
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发表时间：
2006-10-01
影响因子：
13.6
通讯作者：
Nelson, Peter J.
中科院分区：
文献类型：
--
作者：
Albaqumi, Mamdouh;Soos, Timothy J.;Nelson, Peter J.
塌陷性肾小球病（CG）已成为终末期肾病的重要病因。CG在20世纪80年代首次从其他蛋白尿性肾小球病变中被描述出来，现在被认为是一种常见的、独特的增生性实质损伤模式，预示着肾功能的快速丧失和对经验性治疗的不良反应。尽管如此，与CG相关的疾病的增加，CG的第一个易感基因的鉴定，CG的小鼠模型的显着增加，以及新的治疗策略的有希望的临床前测试表明，CG作为一种了解不多和治疗耐药的肾脏疾病的前景将在未来发生变化。本文重点综述了CG发病机制和治疗研究的最新进展。
Collapsing glomerulopathy (CG) has become an important cause of ESRD. First delineated from other proteinuric glomerular lesions in the 1980s, CG is now recognized as a common, distinct pattern of proliferative parenchymal injury that portends a rapid loss of renal function and poor responses to empiric therapy. Notwithstanding, the rise in disorders that are associated with CG, the identification of the first susceptibility genes for CG, the remarkable increase in murine modeling of CG, and promising preclinical testing of new therapeutic strategies suggest that the outlook for CG as a poorly understood and therapeutically resistant renal disease is set to change in the future. This focused review highlights recent advances in research into the pathogenesis and treatment of CG.