Continuous-Flow Precipitation of Hydroxyapatite at 37 °C in a Meso Oscillatory Flow Reactor
Continuous-Flow Precipitation of Hydroxyapatite at 37 °C in a Meso Oscillatory Flow Reactor
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DOI：
10.1021/ie400710b
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发表时间：
2013-07-24
影响因子：
4.2
通讯作者：
Teixeira, Jose Antonio
中科院分区：
文献类型：
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作者：
Castro, Filipa;Ferreira, Antonio;Teixeira, Jose Antonio
研究了在介观振荡反应器(MESO-OFR)和放大介观振荡反应器(MESO-OFR)中连续流沉淀羟基磷灰石(HAP)的过程。实验在接近生理的温度和pH条件下进行，使用固定频率(f=0.83 Hz)和幅度(x(0)=4.5 mm)，停留时间从0.4到6.7min变化。结果表明，随着停留时间的减少，制得的羟基磷灰石粒子的平均粒径和聚集度减小。在介观氧化还原和放大介观氧化还原体系中，HAP纳米粒子的平均粒径(d(50))为77 nm，粒径分布窄，形貌均匀，停留时间最短，介观氧化还原时间为0.4min，放大介观氧化还原反应时间为3.3min。这些结果显示了介观OFR和放大的介观OFR连续生产均匀的HAP纳米颗粒的能力，同时也证实了通过串联单个OFR来放大OFR的可能性。
Continuous-flow precipitation of hydroxyapatite (HAp) was investigated in a meso oscillatory flow reactor (meso-OFR) and in a scaled-up meso-OFR, obtained by associating in series eight vertical meso-ORFs. Experiments were carried out under near-physiological conditions of temperature and pH, using fixed frequency (f = 0.83 Hz) and amplitude (x(0) = 4.5 mm), and varying the residence time from 0.4 to 6.7 min. It has been shown that the mean particle size and the aggregation degree of the prepared HAp particles decrease with decreasing residence time. HAp nanoparticles with a mean size (d(50)) of 77 nm, narrow size distribution, and uniform morphology were obtained at the lowest residence times, tau = 0.4 and 3.3 min in the meso-OFR and the scaled-up meso-OFR, respectively. These results show the capability of the meso-OFR and the scaled-up meso-OFR for continuous production of uniform HAp nanoparticles, while also confirming the possibility of OFR scale-up by in series association of individual OFRs.