Knowledge about HBV, Prevention Behaviour and Treatment Adherence of Patients with Chronic Hepatitis B in a Large Referral Centre in Germany
Knowledge about HBV, Prevention Behaviour and Treatment Adherence of Patients with Chronic Hepatitis B in a Large Referral Centre in Germany
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DOI：
10.1055/s-0029-1245304
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发表时间：
2010-09-01
影响因子：
1.3
通讯作者：
Petersen, J.
中科院分区：
文献类型：
--
作者：
Lutgehetmann, M.;Meyer, F.;Petersen, J.
背景：德国慢性B型肝炎的发病率约为0.5%。关于HBV的知识，预防行为和治疗依从性的慢性HBV.Methods患者的数据是稀缺的：在这项前瞻性研究中，201例连续慢性乙型肝炎感染的患者进行了研究，从一个大型的城市学术门诊在汉堡大学医学中心。对患者进行了问卷调查，其中包括47个问题，包括社会人口统计学数据，HBV知识，治疗依从性和预防。结果：20.4%的CHB患者出生在德国，但大多数患者是移民（80.6%）。51%的患者对HBV相关知识的掌握程度为良好，34%为中等，15%为较差。89%的患者知道HBV可以通过血液接触传播，但34%的患者认为卫生条件差和24%的患者认为食品可能传播病毒。96%的患者知道HBV疫苗的存在。此外，82%的人认为家庭中所有人都接种疫苗很重要。尽管知道疫苗的存在和重要性，但在300名受影响的儿童/HBV阳性家庭成员的兄弟姐妹中，只有61.7%接种了疫苗。然而，在了解疫苗保护作用的患者中（p <0.001），18岁以下儿童免费接种计划（p <0.001）和高等教育（p <0.001）的儿童接种率明显较高。与德语技能良好的移民相比，德语技能差的移民的知识得分较低（p <0.001），接种率较低（p = 0.016）。43%的患者接受核苷类似物治疗，中位治疗持续时间为2 - 5年。这些患者中有65%声称从未漏服过一剂，27%每月漏服不到一剂。90%的患者耐受的抗病毒药物非常好，或没有副作用的患者之间没有显着差异的生活quality. Conclusion：慢性肝炎B在德国的特点是认识问题和语言障碍。需要更多地关注HBV感染的移民，提供有关CHB的多语种信息和宣传活动。
Background: The incidence of chronic hepatitis B in Germany is approximately 0.5%. Data regarding knowledge about HBV, prevention behaviour and treatment adherence in patients with chronic HBV are scarce.Methods: In this prospective study 201 consecutive patients with CHB infection were studied from a large urban academic outpatient clinic at the University Medical Centre in Hamburg. Patients were interviewed with a questionnaire that contained 47 questions covering social demographic dates, knowledge about HBV, treatment adherence and prevention. The success rate of interviews was 100% with free translation service offered.Results: 20.4% of the CHB patients were born in Germany, but the majority of the patients were immigrants (80.6%). 51% of the patients had a good, 34% a moderate and 15% a poor knowledge about HBV. 89% of the patients knew that HBV can be transmitted through blood contacts, but 34% believed that inadequate hygienic conditions and 24% that food products may transmit the virus. 96% of the patients had knowledge about the existence of an HBV vaccine. Furthermore, 82% considered a vaccination of all persons in the household important. Despite the knowledge of the existence and importance of a vaccine, only 61,7% of the 300 affected children/siblings of HBV-positive family members were vaccinated. However, the child vaccination rate was significantly higher among patients with knowledge about the protective effect of the vaccine (p < 0.001), the free of charge vaccination program for children up to 18 years (p < 0.001) and higher school education (p < 0.001). Migrants with poor German language skills had lower knowledge scores (p < 0.001) and showed lower vaccination rates (p = 0.016) compared to immigrants with good German language skills. 43% of all patients were treated with nucleot(s)ide analogues with a median treatment duration of 2 - 5 years. 65% of these patients declared to never have missed a dose and 27% missed less than one dose per month. 90% of the patients tolerated the antiviral drugs very well and between patients with or without side effects there was no significant difference in quality of life.Conclusion: Chronic hepatitis B in Germany is characterised by awareness problems and language barriers. More attention is needed for HBV-infected immigrants in the form of multilingual information about CHB and awareness campaigns.