Plasma soluble corin in patients with heart failure.
Plasma soluble corin in patients with heart failure.
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DOI：
10.1161/circheartfailure.109.903849
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发表时间：
2010-03
期刊：
影响因子：
--
通讯作者：
Wu Q
中科院分区：
文献类型：
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作者：
Dong N;Chen S;Yang J;He L;Liu P;Zheng D;Li L;Zhou Y;Ruan C;Plow E;Wu Q
Corin是一种跨膜蛋白酶，在心脏中处理利钠肽。像许多膜蛋白一样，蛋白蛋白从细胞表面脱落。在这项研究中，我们从健康对照和心力衰竭（HF）和急性心肌梗死（AMI）患者中获得血浆样本。采用ELISA法测定血浆可溶性科林水平。在健康成人（n=198）中，血浆corin水平为690 (SD 260) pg/mL。不同年龄组的科林水平无显著差异。在HF患者（n=291）中，血浆corin水平显著低于健康对照组（365 (SD 259) pg/mL, p<0.001）。血浆corin水平的降低似乎与HF的严重程度有关。在纽约心脏协会（NYHA） II、III和IV级患者中，血浆corin水平分别为450 (SD 281) （n=69）、377 (SD 270) （n=132）和282 (SD 194) (n=90) pg/mL （II类vs. IV类p<0.001； III类vs. IV类p<0.05）。相比之下，AMI患者（n=73）血浆corin水平与健康对照组相似（678 (SD 285) pg/mL, p < 0.05）。在人血浆中检测到可溶性科林。心衰患者血浆蛋白水平显著降低，AMI患者血浆蛋白水平无显著降低。我们的研究结果表明，血浆corin缺乏可能与HF的发病机制有关，血浆corin可作为HF诊断的生物标志物。
Corin is a transmembrane protease that processes natriuretic peptides in the heart. Like many membrane proteins, corin is shed from the cell surface. In this study, we obtained plasma samples from healthy controls and patients with heart failure (HF) and acute myocardial infarction (AMI). Soluble corin levels in plasma were measured by an ELISA method. In healthy adults (n=198), plasma corin levels were 690 (SD 260) pg/mL. The corin levels did not differ significantly among different age groups. In patients with HF (n=291), plasma corin levels were significantly lower compared to that of healthy controls (365 (SD 259) pg/mL, p<0.001). The reduction in plasma corin levels appeared to correlate with the severity of HF. In patients of New York Heart Association (NYHA) classes II, III and IV, plasma corin levels were 450 (SD 281) (n=69), 377 (SD 270) (n=132), and 282 (SD 194) (n=90) pg/mL, respectively (p<0.001 class II vs. IV; p<0.05 class III vs. IV). In contrast, plasma corin levels in patients with AMI (n=73) were similar to that of healthy controls (678 (SD 285) pg/mL, p>0.05). Soluble corin was detected in human plasma. Plasma corin levels were reduced significantly in patients with HF but not AMI. Our results indicate that corin deficiency may contribute to the pathogenesis of HF and that plasma corin may be used as a biomarker in the diagnosis of HF.