Relationship between plasma mid-regional pro-adrenomedullin level and resistance to antihypertensive therapy in stable kidney transplant recipients
Relationship between plasma mid-regional pro-adrenomedullin level and resistance to antihypertensive therapy in stable kidney transplant recipients
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DOI：
10.1016/j.peptides.2013.08.001
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发表时间：
2013-10-01
期刊：
影响因子：
3
通讯作者：
Takeyama, Masaharu
中科院分区：
文献类型：
--
作者：
Suzuki, Yosuke;Itoh, Hiroki;Takeyama, Masaharu
我们研究了稳定的肾移植受者血浆中区域肾上腺髓质素原（MR-proADM）样免疫反应物质（IS）水平与肾功能衰竭或抗高血压治疗抵抗相关的临床特征之间的关系。纳入了46名在研究前90天以上接受移植的日本肾移植受者。为了评估抗高血压治疗的抵抗力，我们计算了每位接受者抗高血压药物的治疗强度评分。采集早晨血样，并使用酶免疫测定法测量血浆MR-proADM-IS水平。血浆MR-proADM-IS水平与肌酐清除率或治疗强度评分之间存在显著相关性。多元回归分析确定血浆MR-proADM水平和体重指数是与治疗强度评分相关的重要独立因素。血浆MR-proADM水平可能是一个有用的生物标志物，指示抗高血压治疗的抵抗程度。(C)2013 Elsevier Inc. All rights reserved.
We investigated the relationship between plasma mid-regional pro-adrenomedullin (MR-proADM)-like immunoreactive substance (IS) level and clinical characteristics associated with renal failure or resistance to antihypertensive therapy in stable kidney transplant recipients. Forty-six Japanese kidney transplant recipients who underwent transplantation more than 90 days prior to the study were included. To evaluate resistance to antihypertensive therapy, we calculated the treatment intensity score of the antihypertensive drugs in each recipient. Morning blood samples were collected and plasma MR-proADM-IS levels were measured using an enzyme immunoassay. A significant correlation was observed between plasma MR-proADM-IS level with creatinine clearance or treatment intensity score. Multiple regression analysis identified plasma MR-proADM level and body mass index as significant independent factors associated with treatment intensity score. Plasma MR-proADM level may be a useful biomarker indicating the degree of resistance to antihypertensive therapy. (C) 2013 Elsevier Inc. All rights reserved.