Effect of nodule characteristics on variability of semiautomated volume measurements in pulmonary nodules detected in a lung cancer screening program
Effect of nodule characteristics on variability of semiautomated volume measurements in pulmonary nodules detected in a lung cancer screening program
复制标题
DOI：
10.1148/radiol.2482070957
复制
发表时间：
2008-08-01
期刊：
影响因子：
19.7
通讯作者：
Oudkerk, Matthijs
中科院分区：
文献类型：
--
作者：
Wang, Ying;van Klaveren, Rob J.;Oudkerk, Matthijs
目的：回顾性评估肺癌筛查中检测到的实性肺结节（体积，15-500 mm(3)）的体积测量变异性，并量化结节形态、大小和位置的独立影响。材料和方法：这项回顾性研究是荷兰卫生部批准的筛查计划的子研究，所有参与者都提供了书面知情同意书。两名独立读者使用半自动软件测量了 6774 名 50-75 岁参与者（5917 名男性）中检测到的肺结节体积。结节根据其位置（纯实质内、基于胸膜、血管旁或裂隙附着）、形态（光滑、多分叶、针状或不规则）和大小（50 mm3）进行分类。一致性程度通过使用相对体积差（RVD）的绝对值来表示。进行多变量逻辑回归分析，并计算比值比 (OR) 以量化形态、位置和大小对 RVD 类别的独立影响。结果：总共纳入了 2239 名参与者的 4225 个结节。 3646 个 (86%) 结节的体积完全一致。 173 个 (4%) 结节差异较小（RVD 绝对值 < 5%），232 个（6%）结节差异中等（RVD 绝对值 >= 5% 但 < 15%），174 个结节（4%）差异较大（RVD 绝对值 >= 15%）。多变量分析显示，对于不规则结节、针状结节和多分叶结节，体积不一致的 OR 分别为 15.7、3.1 和 1.9；血管旁结节、胸膜结节和裂隙附着结节分别为 3.5、2.6 和 2.1； 1.3 对于大结节与光滑、纯实质内和小参考结节进行比较。结论：结节的形态、位置和大小影响体积测量的变异性，特别是对于血管旁结节和不规则结节。 (C) 北美放射学会，2008 年。
Purpose: To retrospectively assess volume measurement variability in solid pulmonary nodules (volume, 15-500 mm(3)) detected at lung cancer screening and to quantify the independent effects of nodule morphology, size, and location.Materials and Methods: This retrospective study was a substudy of the screening program that was approved by the Dutch Ministry of Health, and all participants provided written informed consent. Two independent readers used semiautomated software to measure the volume of pulmonary nodules detected in 6774 participants aged 50-75 years (5917 men). Nodules were classified according to their location (purely intraparenchymal, pleural based, juxtavascular, or fissure attached), morphology (smooth, polylobulated, spiculated, or irregular), and size (50 mm3). The level of agreement was expressed by using the absolute values of the relative volume differences (RVDs). Multivariate logistic regression analysis was performed, and odds ratios (ORs) were computed to quantify the independent effects of morphology, location, and size on RVD categories.Results: Altogether, 4225 nodules in 2239 participants were included. Complete agreement in volume was obtained for 3646 (86%) of the nodules. Disagreement was small (absolute value of RVD < 5%) for 173 (4%) nodules, moderate (absolute value of RVD >= 5% but < 15%) for 232 (6%), and large (absolute value of RVD >= 15%) for 174 (4%). Multivariate analysis showed that the ORs of volume disagreement were 15.7, 3.1, and 1.9 for irregular, spiculated, and polylobulated nodules, respectively; 3.5, 2.6, and 2.1 for juxtavascular, pleural-based, and fissure-attached nodules, respectively; and 1.3 for large nodules compared with smooth, purely intraparenchymal, and small reference nodules.Conclusion: Nodule morphology, location, and size influence volume measurement variability, particularly for juxtavascular and irregular nodules. (C) RSNA, 2008.