Catalytic enantioselective desymmetrization of meso cyclic anhydrides via iridium-catalyzed hydrogenation.
Catalytic enantioselective desymmetrization of meso cyclic anhydrides via iridium-catalyzed hydrogenation.
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DOI：
10.1021/ol400533g
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发表时间：
2013-03
期刊：
影响因子：
5.2
通讯作者：
Tang‐Lin Liu;Wei Li;H. Geng;Chun‐Jiang Wang;Xumu Zhang
中科院分区：
文献类型：
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作者：
Tang‐Lin Liu;Wei Li;H. Geng;Chun‐Jiang Wang;Xumu Zhang
开发了一种通过 Ir-C3*-TunePhos 络合物催化的不对称氢化将内消旋酸酐去对称转化为内酯的新方法。在高反应温度下合成了多种手性内酯，转化完全，具有优异的对映选择性。
A novel method to desymmetrize meso-anhydrides into lactones via asymmetric hydrogenation catalyzed by the Ir-C3*-TunePhos complex has been developed. Various chiral lactones were synthesized with full conversion and excellent enantioselectivity under high reaction temperature.