Increased rostral medial frontal GABA+ in early psychosis is obscured by levels of negative affect.
Increased rostral medial frontal GABA+ in early psychosis is obscured by levels of negative affect.
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早期精神病中头内侧额叶 GABA 的增加被负面情绪的水平所掩盖。
DOI：
10.1016/j.schres.2022.12.017
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发表时间：
2023
影响因子：
4.5
通讯作者：
Taylor,StephanF
中科院分区：
文献类型：
--
作者：
Simmonite,Molly;Yao,Beier;Welsh,RobertC;Taylor,StephanF
GABA能系统功能障碍与精神分裂症和其他精神病谱系障碍有关（Taylor和Tso，2015）。使用苯二氮卓类激发与fMRI组合，我们的小组已经证明了精神分裂症中的GABA能功能障碍，而患者被动地观看情绪突出的图像（Taylor等人，2014）和在执行面部处理任务时（Tso et al.，2015）。此外，精神分裂症患者对苯二氮卓类药物的血氧水平依赖性（BOLD）反应改变与负性情绪（NA）增加呈正相关。这些新兴的GABA能系统之间的联系，影响和情绪处理表明了一个重要的调查线。在这里，我们的目的是建立在这些发现的基础上，探索这些联系使用磁共振波谱（MRS）。到目前为止，使用MRS对精神分裂症中GABA浓度的研究已经报道了混合的发现（Egerton等人，2017; Nakahara等人，2021; Simmonite等人，2022），可能反映了多种因素对GABA能系统的影响，如疾病阶段和异质性症状表现。为了解决这个问题，我们比较了患有首次发作精神病（FEP）的患者和符合减轻精神病综合征（APS）标准的个体中的嘴侧MFC和中线枕叶皮质中的GABA+浓度，以及健康对照参与者，测试了通过心理应激指数（PSI 9：Tso et al.，2012），将与嘴侧MFC中GABA+信号减少相关。基于早期精神分裂症中嘴侧MFC GABA增加的先前报道（Chen等人，2017; de la Fuente-
Dysfunction of GABAergic systems has been implicated in schizophrenia and other psychosis spectrum disorders (Taylor and Tso, 2015). Using a benzodiazepine challenge in combination with fMRI, our group has demonstrated GABAergic dysfunction in schizophrenia both while patients passively viewed emotionally salient images (Taylor et al., 2014) and while performing a face processing task (Tso et al., 2015). Further, the altered blood oxygen level-dependent (BOLD) response to the benzodiazepine in schizophrenia was positively correlated with increased negative affect (NA). These emerging links between GABAergic systems, affect and emotion processing indicate an important line of inquiry.Here, we aimed to build upon these findings by exploring these links using Magnetic Resonance Spectroscopy (MRS). Thus far, studies of GABA concentrations in schizophrenia using MRS have reported mixed findings (Egerton et al., 2017; Nakahara et al., 2021; Simmonite et al., 2022), likely reflecting the influence of multiple factors upon GABAergic systems, such as illness stage and heterogeneous symptom presentations. To address this issue, we compared GABA+ concentrations in the rostral MFC and midline occipital cortex in patients with first episode psychosis (FEP) and individuals meeting criteria for attenuated psychosis syndrome (APS), with healthy control participants, testing the hypothesis that negative affect (NA), measured by the Psychological Stress Index (PSI9: Tso et al., 2012), would be associated with reduced GABA+ signal in the rostral MFC. Based on prior reports of increased rostral MFC GABA in early schizophrenia (Chen et al., 2017; de la Fuente-