Standardized Outcome and Reporting Measures in Pediatric Head and Neck Lymphatic Malformations
Standardized Outcome and Reporting Measures in Pediatric Head and Neck Lymphatic Malformations
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DOI：
10.1177/0194599815577602
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发表时间：
2015-05-01
影响因子：
3.4
通讯作者：
Elluru, Ravindhra G.
中科院分区：
文献类型：
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作者：
Balakrishnan, Karthik;Bauman, Nancy;Elluru, Ravindhra G.
目的探讨头颈部淋巴畸形（HNLM）的综合治疗和局部治疗效果及预后指标，以规范头颈部淋巴畸形（HNLM）的治疗报告。研究设计共识声明/专家意见。多所高等院校。改进的德尔菲法是一个收集专家意见，通过讨论和反馈提炼意见，统计汇总意见，并在缺乏其他数据的情况下利用这些意见形成共识意见的迭代过程。由多机构耳鼻喉科和血管异常领域的介入放射学专家组成的小组使用改进的德尔菲法制定了头颈部淋巴畸形研究和治疗的推荐报告结果清单。通过3轮迭代，10名专家小组成员对98项建议的结果测量指标和9个结果类别进行了细化，最终形成了3个总体类别（一般、人口统计学和治疗并发症）和5个部位特定类别（眼眶、口腔、咽、喉和颈部）的50项推荐结果的共识集。我们提出了第一套关于hnlm临床和治疗结果的标准化报告标准。在未来的研究中，一致的结果测量将促进治疗方案的比较，并允许系统评价。我们希望这些指南有助于设计和报告后续的HNLM研究。
Objective To develop general and site-specific treatment effect and outcome measures to standardize the reporting of head and neck lymphatic malformation (HNLM) treatments.Study Design Consensus statement/expert opinion.Setting Multiple tertiary academic institutions.Subjects and Methods The modified Delphi method is an iterative process of collecting expert opinions, refining opinions through discussion and feedback, statistically aggregating opinions, and using these aggregates to generate consensus opinion in the absence of other data. The modified Delphi method was used by a multi-institutional group of otolaryngology and interventional radiology experts in the field of vascular anomalies to formulate a list of recommended reporting outcomes for the study and treatment of head and neck lymphatic malformations.Results Through 3 rounds of iteration, 10 expert panelists refined 98 proposed outcome measures and 9 outcome categories to a final consensus set of 50 recommended outcome measures in 3 global categories (general, demographics, and treatment complications) and 5 site-specific categories (orbit, oral cavity, pharynx, larynx, and neck).Conclusions We propose the first consensus set of standardized reporting measures for clinical and treatment outcomes in studies of HNLMs. Consistent outcome measures across future studies will facilitate comparison of treatment options and allow systematic review. We hope that these guidelines facilitate the design and reporting of subsequent HNLM studies.