ANTIBIOTIC MAGAININS EXERT CYTOLYTIC ACTIVITY AGAINST TRANSFORMED-CELL LINES THROUGH CHANNEL FORMATION
ANTIBIOTIC MAGAININS EXERT CYTOLYTIC ACTIVITY AGAINST TRANSFORMED-CELL LINES THROUGH CHANNEL FORMATION
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DOI：
10.1073/pnas.88.9.3792
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发表时间：
1991-05-01
影响因子：
11.1
通讯作者：
COLAMONICI, O
中科院分区：
文献类型：
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作者：
CRUCIANI, RA;BARKER, JL;COLAMONICI, O
蛙皮素是一类具有离子载体作用的脊椎动物肽，对多种微生物具有抗菌活性。在此我们表明，蛙皮素2及合成类似物能够快速且不可逆地裂解造血肿瘤和实体肿瘤靶细胞，其相对细胞毒性效力与其抗菌功效平行，且在对分化良好的细胞相对无毒的浓度下即可发挥作用。细胞去极化可阻止这种细胞毒性。蛙皮素是脊椎动物中的一种天然溶细胞剂，可能为某些肿瘤提供另一种治疗策略。
Magainins are an ionophoric class of vertebrate peptides with antibiotic activity against various microorganisms. Here we show that magainin 2 and synthetic analogues can rapidly and irreversibly lyse hematopoietic tumor and solid tumor target cells with a relative cytotoxic potency that parallels their antibacterial efficacy and at concentrations that are relatively nontoxic to well-differentiated cells. The cytotoxicity is prevented by cell depolarization. Magainins represent a natural cytolytic agent in vertebrates and may provide another therapeutic strategy for certain tumors.