Assessing the Relationship Between Antigenicity and Immunogenicity of Human Rabies Vaccines
Assessing the Relationship Between Antigenicity and Immunogenicity of Human Rabies Vaccines
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DOI：
10.4161/hv.1.5.2110
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发表时间：
2005-09-01
期刊：
影响因子：
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通讯作者：
Anandagiri, M. S.
中科院分区：
文献类型：
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作者：
Sudarshan, M. K.;Mahendra, B. J.;Anandagiri, M. S.
对人用狂犬病疫苗抗原性与免疫原性的关系进行Meta分析。本研究使用了1993-2004年期间在一个中心进行的10项细胞培养人用狂犬病疫苗研究的数据。研究的疫苗包括纯化鸡胚细胞疫苗（Kaketsuken，日本和Rabipur，印度）、纯化Vero细胞狂犬病疫苗（Verorab，法国）、人二倍体细胞疫苗（MIRV，法国和Rabivax，吸附和冻干，印度）和恒河猴二倍体狂犬病疫苗（吸附，美国）。有趣的是，狂犬病疫苗的较高抗原性，即每单次肌肉注射>= 5 IU的效力，并没有导致显著较高的免疫原性，如通过接种者中狂犬病病毒中和抗体（RVNA）滴度所测量的，均在第14天（t = 0.42，p > 0.66，GMR = 1.06，GMR的95%CI = 0.82，1.37）和第90天（t = 0.80，p > 0.43，GMR = 1.15，GMR的95%CI = 0.74，1.14）。然而，由于没有关于细胞培养人用狂犬病疫苗试验荟萃分析的报告，为了证实这一观察结果，作者建议在这方面进行进一步研究。
A meta-analysis was done to study the relationship between antigenecity and immunogenecity of human rabies vaccines. The data of ten cell culture human rabies vaccine studies conducted at a single centre during 1993-2004 were used in the study. The vaccines studied included Purified Chick Embryo Cell Vaccine (Kaketsuken, Japan and Rabipur, India), Purified Vero cell Rabies Vaccine (Verorab, France), Human Diploid Cell Vaccine (MIRV, France and Rabivax, Adsorbed and Lyophilized, India) and Rhesus Diploid Rabies Vaccine (adsorbed, USA). Interestingly, it was revealed that an higher antigenecity of rabies vaccines viz. potency of >= 5 IU per single intramuscular dose did not result in significantly higher immunogenecity, as measured by rabies virus neutralizing antibody (RVNA) titers in the vaccinees, both on day14(t = 0.42, p > 0.66, GMR = 1.06, 95% CI of GMR = 0.82, 1.37) and day 90 (t = 0.80, p > 0.43, GMR = 1.15, 95% CI of GMR = 0.74, 1.14). However, as there are no reports of meta-analysis of cell culture human rabies vaccine trials, to confirm this observation the authors recommend further studies in this regard.