Whole grains and risk of pancreatic cancer in a large population-based case-control study in the San Francisco Bay Area, California
Whole grains and risk of pancreatic cancer in a large population-based case-control study in the San Francisco Bay Area, California
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DOI：
10.1093/aje/kwm194
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发表时间：
2007-11-15
影响因子：
5
通讯作者：
Holly, Elizabeth A.
中科院分区：
文献类型：
--
作者：
Chan, June M.;Wang, Furong;Holly, Elizabeth A.
流行病学数据表明，食用全麦食品可能与患胰腺癌的风险呈负相关。在旧金山湾区一项以人群为基础的胰腺癌病例对照研究（1995-1999）中，对谷物摄入量进行了检查。对532例患者和1701名对照者进行了一份包含131项的半定量食物频率问卷调查。计算比值比和95%置信区间作为相对风险的估计值。每天食用100份= 2份全谷物的人患胰腺癌的风险低于每天食用< 1份的人(优势比(OR) = 0.60, 95%可信区间（CI）： 0.31, 1.2；trend-p = 0.04)。糙米（OR = 0.72, 95% CI: 0.44, 1.2；趋势p = 0.01）和玉米饼（OR = 0.56, 95% CI: 0.35, 0.89；趋势p = 0.02）的结果相似。食用甜甜圈（>= 2份/周vs < 1份/月）会增加风险（OR = 1.8, 95% CI: 1.2, 2.7；趋势p = 0.003）。食用煮熟的早餐谷物（>= 2份/周vs. < 1份/月）与风险呈正相关（燕麦片/燕麦麸，OR = 1.3, 95% CI: 1.0, 1.7；其他煮熟的早餐谷物，OR = 2.1, 95% CI: 1.4, 3.3）。膳食纤维与风险呈负相关（最高四分位数vs最低四分位数，OR = 0.65, 95% CI: 0.47, 0.89；趋势p = 0.02）。这些数据为多吃全麦或高纤维食物可能降低患胰腺癌风险的假设提供了一些支持。精制谷物与风险无关。
Epidemiologic data suggest that consumption of whole-grain products may be inversely associated with risk of pancreatic cancer. Grain intake was examined in a population-based case-control study of pancreatic cancer in the San Francisco Bay Area (1995-1999). A 131-item semiquantitative food frequency questionnaire was administered to 532 cases and 1,701 controls. Odds ratios and 95% confidence intervals were computed as estimates of relative risk. Persons who consumed >= 2 servings of whole grains daily had a lower risk of pancreatic cancer than persons who consumed < 1 serving/day (odds ratio (OR) = 0.60, 95% confidence interval (CI): 0.31, 1.2; trend-p= 0.04). Similar results were observed for brown rice (OR = 0.72, 95% CI: 0.44, 1.2; trend-p = 0.01) and tortillas (OR = 0.56, 95% CI: 0.35, 0.89; trend-p = 0.02). Consumption of doughnuts (>= 2 servings/week vs. < 1 serving/month) conferred increased risk (OR = 1.8, 95% CI: 1.2, 2.7; trend-p = 0.003). Consumption of cooked breakfast cereals (>= 2 servings/week vs. < 1 serving/month) was positively associated with risk (for oatmeal/oat bran, OR = 1.3, 95% CI: 1.0, 1.7; for other cooked breakfast cereals, OR = 2.1, 95% CI: 1.4, 3.3). Dietary fiber was inversely associated with risk (for highest quartile vs. lowest, OR = 0.65, 95% CI: 0.47, 0.89; trend-p = 0.02). These data provide some support for the hypothesis that consuming more whole-grain or high-fiber foods may reduce the risk of pancreatic cancer. Refined grains were not associated with risk.