EFFECTS OF METHOXAMINE AND ALPHA-ADRENOCEPTOR ANTAGONISTS, PRAZOSIN AND YOHIMBINE, ON THE SLEEP-WAKE CYCLE OF THE RAT
EFFECTS OF METHOXAMINE AND ALPHA-ADRENOCEPTOR ANTAGONISTS, PRAZOSIN AND YOHIMBINE, ON THE SLEEP-WAKE CYCLE OF THE RAT
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DOI：
10.1093/sleep/7.4.365
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发表时间：
1984-01-01
期刊：
影响因子：
5.6
通讯作者：
HAWKINS, M
中科院分区：
文献类型：
--
作者：
PELLEJERO, T;MONTI, JM;HAWKINS, M
研究了甲氧胺、哌唑嗪和育亨宾对准备进行慢性睡眠记录的大鼠睡眠-觉醒周期的影响。甲氧胺（4-8 mg/kg），一种α1-肾上腺素受体激动剂，诱导剂量相关的觉醒（W）增加，慢波睡眠（SWS）和REM睡眠（REMS）减少。哌唑嗪（0.125-1 mg/kg）选择性阻断肾上腺素能受体，仅略微改变Wand SWS中花费的时间，并持续降低REMS值。哌唑嗪（0.5 mg/kg）可逆转甲氧胺的作用，降低W和增加睡眠。育亨宾（3 mg/kg），阻断α2-肾上腺素受体，增加Wand减少睡眠。在育亨宾（3 mg/kg）预处理的动物中，甲氧胺（4 mg/kg）可进一步减少SWS和REMS，增加W。因此，药理学激活α 1-肾上腺素受体或阻断α2-肾上腺素受体似乎可减少睡眠，增加W。α1-激动剂或α1-拮抗剂引起的快速眼动睡眠抑制暂时归因于脑中去甲肾上腺素能传递的关键变化。
A study was carried out on the effects of methoxamine, prazosin, and yohimbine on the sleep-wake cycle in rats prepared for chronic sleep recordings. Methoxamine (4-8 mg/kg), an α1-adrenoceptor agonist, induced a doserelated increase in wakefulness (W) and a decrease in slow-wave sleep (SWS) and REM sleep (REMS). Prazosin (0.125-1 mg/kg), which selectively blocks aladrenoceptors, modified only slightly the amount of time spent in Wand SWS, and consistently decreased REMS values. Prazosin (0.5 mg/kg) reversed the effects of methoxamine, decreasing Wand increasing sleep. Yohimbine (3 mg/kg), which blocks α2-adrenoceptors, augmented Wand diminished sleep. Methoxamine (4 mg/kg) in animals pretreated with yohimbine (3 mg/kg) induced a further decrease of SWS and REMS and an increase of W Thus, pharmacological activation of α1- or blocking of α2-adrenoceptors appears to decrease sleep and increase W Further, blocking of α1-adrenoceptors decreases REMS. Rapid eye movement sleep depression by the α1-agonist or the α1-antagonist is tentatively ascribed to a critical change in noradrenergic transmission in the brain.