Are 90% of deaths from cancer caused by metastases?
Are 90% of deaths from cancer caused by metastases?
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DOI：
10.1002/cam4.2474
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发表时间：
2019-08-08
期刊：
影响因子：
4
通讯作者：
Straume, Oddhjorn
中科院分区：
文献类型：
--
作者：
Dillekas, Hanna;Rogers, Michael S.;Straume, Oddhjorn
许多出版物指出，转移是90%的癌症死亡的原因，但缺乏支持这一论断的数据。我们的目标是确定癌症死亡中有多少比例是由转移引起的。分析了2005-2015年挪威癌症登记处的人口数据。我们比较了挪威人口中所有的死亡，其中癌症诊断被登记为死亡原因。按性别和肿瘤组分析了有和无转移的癌症导致的死亡。对于实体瘤，66.7%的癌症死亡与转移有关。肿瘤组之间的比例差异很大。我们的数据支持这样的观点，即大多数实体瘤死亡是由转移引起的。因此，更好地了解转移的生物学并识别参与转移部位生长的可药物靶点是降低癌症死亡率的一种有希望的策略。
Numerous publications have stated that metastases are responsible for 90% of cancer deaths, but data underlying this assertion has been lacking. Our objective was to determine what proportions of cancer deaths are caused by metastases. Population-based data from the Cancer Registry of Norway for the years 2005-2015 was analyzed. We compared all deaths in the Norwegian population where a cancer diagnosis was registered as cause of death. Deaths caused by cancer, with and without metastases, were analyzed, by sex and tumor group. For solid tumors, 66.7% of cancer deaths were registered with metastases as a contributing cause. Proportions varied substantially between tumor groups. Our data support the idea that the majority of deaths from solid tumors are caused by metastases. Thus, a better understanding of the biology of metastases and identification of druggable targets involved in growth at the metastatic site is a promising strategy to reduce cancer mortality.