Human synaptonemal complex protein 1 (SCP1): Isolation and characterization of the cDNA and chromosomal localization of the gene
Human synaptonemal complex protein 1 (SCP1): Isolation and characterization of the cDNA and chromosomal localization of the gene
复制标题
DOI：
10.1006/geno.1996.4373
复制
发表时间：
1997-02-01
期刊：
影响因子：
4.4
通讯作者：
Heyting, C
中科院分区：
文献类型：
--
作者：
Meuwissen, RLJ;Meerts, I;Heyting, C
联会复合体（Synaptonemal complex，SC）是减数分裂前期同源染色体之间形成的结构。它们由两个蛋白质轴组成，每个同源物沿着一个，它们通过许多横丝（TF）沿其长度沿着连接。编码大鼠干细胞转录因子的一个主要成分rnSCP 1的cDNA最近被分离和鉴定。在本文中，我们描述了分离和鉴定的cDNA编码的人类蛋白质同源rnSCP 1，hsSCP 1。hsSCP 1和rnSCP 1具有75%的氨基酸同一性。rnSCP 1最突出的结构特征和氨基酸序列基序在hsSCP 1中是保守的。最有可能的是，hsSCP 1与rnSCP 1在功能上同源。荧光原位杂交结果显示hsSCP 1基因定位于人染色体1 p12-p13。(C)北京：科学出版社.
Synaptonemal complexes (SCs) are structures that are formed between homologous chromosomes (homologs) during meiotic prophase. They consist of two proteinaceous axes, one along each homolog, that are connected along their length by numerous transverse filaments (TFs). The cDNA encoding one major component of TFs of SCs of the rat, rnSCP1, has recently been isolated and characterized. In this paper we describe the isolation and characterization of the cDNA encoding the human protein homologous to rnSCP1, hsSCP1. hsSCP1 and rnSCP1 have 75% amino acid identity. The most prominent structural features and amino acid sequence motifs of rnSCP1 have been conserved in hsSCP1. Most probably, hsSCP1 is functionally homologous to rnSCP1. The hsSCP1 gene was assigned to human chromosome 1p12-p13 by fluorescence in situ hybridization. (C) 1997 Academic Press.