A Hox regulatory network establishes motor neuron pool identity and target-muscle connectivity
A Hox regulatory network establishes motor neuron pool identity and target-muscle connectivity
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DOI：
10.1016/j.cell.2005.09.009
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发表时间：
2005-11-04
期刊：
影响因子：
64.5
通讯作者：
Jessell, TM
中科院分区：
文献类型：
--
作者：
Dasen, JS;Tice, BC;Jessell, TM
脊髓运动神经元获得了特殊的“池”身份，这决定了它们与肢体中的目标肌肉形成选择性连接的能力，但这个神经元特异性的显著例子的分子基础仍然不清楚。我们在这里表明，HOX转录调控网络指定运动神经元池的身份和连接。两组相互依赖的HOX调控相互作用在运动神经元中起作用，其中一组指定肩尾运动池的位置，另一组在单个节段水平上指导运动池的多样性。这个HOX调控网络指导运动神经元池的下游转录身份，并定义目标肌肉连接的模式。
Spinal motor neurons acquire specialized "pool" identities that determine their ability to form selective connections with target muscles in the limb, but the molecular basis of this striking example of neuronal specificity has remained unclear. We show here that a Hox transcriptional regulatory network specifies motor neuron pool identity and connectivity. Two interdependent sets of Hox regulatory interactions operate within motor neurons, one assigning rostrocaudal motor pool position and a second directing motor pool diversity at a single segmental level. This Hox regulatory network directs the downstream transcriptional identity of motor neuron pools and defines the pattern of target-muscle connectivity.