Mitochondria, Maternal Inheritance, and Male Aging
Mitochondria, Maternal Inheritance, and Male Aging
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DOI：
10.1016/j.cub.2012.07.018
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发表时间：
2012-09-25
期刊：
影响因子：
9.2
通讯作者：
Dowling, Damian K.
中科院分区：
文献类型：
--
作者：
Camus, M. Florencia;Clancy, David J.;Dowling, Damian K.
线粒体基因组的母系传递引发了性别特异性选择筛，线粒体DNA中的突变只能对直接作用于雌性的选择做出反应[1-3]。从理论上讲，这使得男性伤害突变在线粒体基因组中积累，当这些相同的突变对女性的影响是中性的，有益的，或只有轻微的有害[1-3]。最终，这种进化过程可能导致男性特有的线粒体突变负荷的进化;这一想法以前被称为母亲的诅咒[2，4-6]。在这里，我们提出的证据表明，这一过程的影响比迄今为止实现的更广泛，它导致了突变负荷影响男性，但不是女性果蝇的衰老模式。此外，我们的研究结果表明，影响男性衰老的线粒体突变负荷通常包括多个位点的许多突变。因此，我们的研究结果表明，男性受到戏剧性的后果，从线粒体基因组的母亲传输的结果。他们暗示微小的线粒体基因组是影响性别特异性衰老模式的突变的热点，从而促进了线粒体基因组进化中的性别特异性选择性筛选是衰老中的性二态性的促成因素的想法，这在物种中常见[7-9]。
The maternal transmission of mitochondrial genomes invokes a sex-specific selective sieve, whereby mutations in mitochondrial DNA can only respond to selection acting directly on females [1-3]. In theory, this enables male-harming mutations to accumulate in mitochondrial genomes when these same mutations are neutral, beneficial, or only slightly deleterious in their effects on females [1-3]. Ultimately, this evolutionary process could result in the evolution of male-specific mitochondrial mutation loads; an idea previously termed Mother's Curse [2, 4-6]. Here, we present evidence that the effects of this process are broader than hitherto realized, and that it has resulted in mutation loads affecting patterns of aging in male, but not female Drosophila melanogaster. Furthermore, our results indicate that the mitochondrial mutation loads affecting male aging generally comprise numerous mutations over multiple sites. Our findings thus suggest that males are subject to dramatic consequences that result from the maternal transmission of mitochondrial genomes. They implicate the diminutive mitochondrial genome as a hotspot for mutations that affect sex-specific patterns of aging, thus promoting the idea that a sex-specific selective sieve in mitochondrial genome evolution is a contributing factor to sexual dimorphism in aging, commonly observed across species [7-9].