The contribution of ionic contribution of ionic imbalance to ischemia/reperfusion-induced injury
The contribution of ionic contribution of ionic imbalance to ischemia/reperfusion-induced injury
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DOI：
10.1016/s0022-2828(08)80007-7
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发表时间：
1995
影响因子：
5
通讯作者：
G. Pierce;M. Czubryt
中科院分区：
文献类型：
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作者：
G. Pierce;M. Czubryt
许多独立实验室的最新数据表明，心肌内的离子紊乱是缺血/再灌注期间心脏损伤的关键因素。本论文讨论了支持 Ca2+、Na+ 和 K+ 在缺血/再灌注损伤中作用的数据。细胞内离子稳态改变的机制是本综述的重点。特别是，有证据支持通过 Na+/H+ 交换、Na+ 通道和 ATP 敏感的 K+ 通道参与缺血/再灌注损伤中的异常离子运动。
Recent data from a number of independent laboratories have implicated ionic disturbances within the myocardium as being a critical contributory factor in injury to the heart during ischemia/reperfusion. The present treatise discusses the data supporting a role for Ca2+, Na+and K+in ischemic/reperfusion injury. The mechanism whereby intracellular ionic homeostasis becomes altered is the focus of the review. In particular, the evidence in support of an involvement of abnormal ion movements through Na+/H+exchange, Na+channels and the ATP-sensitive K+channel in ischemic/ reperfusion injury is advanced.